Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2279545..2281107 Replicon chromosome
Accession NZ_CP046557
Organism Leclercia sp. 1106151

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GNG29_RS10895 Protein ID WP_156654481.1
Coordinates 2279545..2280852 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GNG29_RS10900 Protein ID WP_156654482.1
Coordinates 2280856..2281107 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNG29_RS10880 2275058..2276239 - 1182 WP_156654478.1 PLP-dependent aminotransferase family protein -
GNG29_RS10885 2276373..2278367 - 1995 WP_156654479.1 TonB-dependent receptor -
GNG29_RS10890 2278378..2279439 - 1062 WP_156654480.1 YncE family protein -
GNG29_RS10895 2279545..2280852 - 1308 WP_156654481.1 type II toxin-antitoxin system HipA family toxin Toxin
GNG29_RS10900 2280856..2281107 - 252 WP_156654482.1 helix-turn-helix domain-containing protein Antitoxin
GNG29_RS10905 2281922..2285713 + 3792 WP_156654483.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 48481.79 Da        Isoelectric Point: 6.6630

>T144500 WP_156654481.1 NZ_CP046557:c2280852-2279545 [Leclercia sp. 1106151]
MRAQRLTVAMNGEVVGTLHRDGSGAMSFQYAPEWLAEPGARAISLSLPLQHGRIRGKQVFNFFSNLLPDSEAIIARMQAR
FQVETAHPFDLLASVGRDCVGAIQLYPPGLEIPSVMDIVAEPLDDEQIASLLEGYQMAPLGMSEEGADFRISLAGAQEKT
ALLWYQDRWQRPQGSTPTSHIFKLPIGRIEQNNIDLSESCENEWLCLRIAKAFGFPVAHAEMATFSRKKVLIIERFDRRW
ASSGWLMRLPQEDFCQALGIAPALKYESHGGPGIADAMKLLLGSRLAAQDREMFFKAQILFWMLAAIDGHGKNFSLFIEA
DSSFRMAPLYDVISAFPLFEAGSIPAKKAKMAMALQGKNRQYHFAMIQPRHFISTAAHAGFSQEIARRLMKEMADRTDEA
IATVRAELPADFPEQISEAIFRGLVSQAARISRFD

Download         Length: 1308 bp

>T144500 NZ_CP062058:4720057-4721379 [Shewanella sp. WPAGA9]
ATGGCCACGCTTGATATCTATATGAATGGCTATTTAGTTGGTGAATTCACTAAATCGCCTACGGGCTCGCATGTATTTCA
GTATGCTAGTCAGTGGTTAGATACGCCAGGCTGCCGCCCAATATCTTTGTCGATGCCGCTACGTGCGCAAAGCTATATAG
GCGATGAGGTCTATAACTTCTTTGACAACCTTTTGCCAGATAATGTTGAGGTGAGAAACAGAATCGTTGCAAGACACAAT
GCCCAATCAACCCAAGCATTCGATTTGCTGGCGAAAGTGGGGCAAGACAGTGTCGGCGCATTGCAGTTTGTACCGCACGG
TCAACAAGCGCTAGACGTTAAAACAATTGAATATAAACCTTTAACCAAGCTCGTTTTAGAAAATATCTTAAAAGGCTACC
AGTCAAACATACCGTTAGGCATGCTAACTGGTGAAGATGATTTTCGGATATCAATTGCAGGTGCACAAGAGAAAACGGCA
CTACTGAATTTAGACGCAATTTATAAAAATGGTTGGTGTTTGCCGATTAAAGCCACTCCCACGACACATATTATTAAATT
ACCTATTGGTAAGATACAAAGTCATTCGCACACCATTGATATGACAGACAGTGTTGAAAATGAACTGTTAAGCATGATGA
TCGTCAGGGAATTTGGCTTAGCGGTGCCGCAATGCTCAATCATCAACACTGCTGATATAAAAGCATTAGCAGTTGAGCGG
TTTGACCGAAAAATATCATCAGACAGTCAATGGATTATGCGTTTACCCCAAGAAGACTTTTGCCAAACCTTGAATGTTCC
ATCGGCCAAAAAATATGAAAGCCATGGAGGCCCTGGGATTAAGCAAATTATGACTTATCTATTGGGCTCTACTAACGCCG
AGAAAGATAGACGAGATTTTATGAAATCCCAAGTGCTGTTTTGGCTTCTCGCAGCAACAGATGGTCATGCGAAAAACTTT
TCACTATTTATCGATGCTGAAGGCGGATACCGGCTAACGCCCTTTTACGATATTTTGTCTATGTACCCAGCAATAGGCGG
TCAAGGGATAAATATCCGTGATGCTAAATTGGCAATGGGACTTAATGGGACCAAAGGCAAAAAGTACGCAGTCGATAAAA
TTTTTCCCAGACATTTTATTCAGACGGCTAAAGCAGTGGGGTTTGACCCAATAGTCATGGCAGAGATATTACAAGAAGTC
GCTGAAACCGTGGATGAAGTGATTAAACGAGTCACAGCTAGGTTACCAGATGACTTTCCTGCTCATATCAGGGAATCAAT
TCTGAATGGGTTAACTGATAGGGCTAAAAGGCTGTCAATGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9238.53 Da        Isoelectric Point: 8.6793

>AT144500 WP_156654482.1 NZ_CP046557:c2281107-2280856 [Leclercia sp. 1106151]
MKVTSAGALAQAVKDQRKVNKLTQSETAEQVGIKQTTVSDFENKPESTKLETLFKILSALDLELHVVKRGSTLPDHASWT
KEW

Download         Length: 252 bp

>AT144500 NZ_CP062058:4719776-4720057 [Shewanella sp. WPAGA9]
ATGAAGGTAACAAACTCAAAGCAACTTAGTGCATACCTTAAAGATGCACGACTGAATATGAAGCTGACTCAAAGCAAAGT
GGCAAGTAAAGTGGGTATTCGCCAAGATACTGTTTCAAGCTTTGAGCAAAACCCCGACTCAACCAAAGTTGAAACCTTAT
TTAAAATCTTATCTGCACTCAATTTAGAGCTCGACATTAAAGTAAGAAGCACTGAGCCAGAAAGTCAGCTAACCAGTGAT
GGTGGCAAGGTTGCTGAGTCACACTGGAAAGAGGAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References