Detailed information of TA system TA144497

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 544608..545124
• Replicon: chromosome
• Accession: NZ_CP046557
• Organism: Leclercia sp. 1106151

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GNG29_RS02635
• Protein ID: WP_156653790.1
• Coordinates: 544840..545124 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GNG29_RS02630
• Protein ID: WP_103178029.1
• Coordinates: 544608..544850 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GNG29_RS02615	540669..541409	+	741	WP_103178026.1	KDGP aldolase family protein	-
GNG29_RS02620	541464..542600	+	1137	WP_156653788.1	lactonase family protein	-
GNG29_RS02625	542620..544530	+	1911	WP_156653789.1	PRD domain-containing protein	-
GNG29_RS02630	544608..544850	+	243	WP_103178029.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GNG29_RS02635	544840..545124	+	285	WP_156653790.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GNG29_RS02640	545128..545592	-	465	WP_156653791.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
GNG29_RS02645	545699..547837	-	2139	WP_156653792.1	anaerobic ribonucleoside-triphosphate reductase	-
GNG29_RS02650	548208..549863	-	1656	WP_156653793.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-65)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10840.65 Da
• Isoelectric Point: 10.5826

>T144497 WP_156653790.1 NZ_CP046557:544840-545124 [Leclercia sp. 1106151]
MTYELEFDPRALKEWQKLGDTVKSQFKKKLAVVLSNPRRESARLHGLPGCYKIKLSSSGYRLVYQVRDKVITVFVVAVGK
REKSAVYHDANQRL

Nucleotide

• Length: 285 bp

>T144497 NZ_CP062008:766271-766708 [Mycolicibacterium mucogenicum DSM 44124]
ATGGCAAAGCTCGCAAGTTCCATCGAAGTACCGCTGTCGCCCGATAAGGCCTGGGAGGCAGCGTCGGACCTCTCCCGGTA
TGACGACTGGCTCTCCATCCACCGGATGTGGCGCAGCCGGTTGCCCGAGACCTTGGGGAAGGGCACGCAGATCTCTTCCG
TCGTCGAGGTCAAGGGCATGCTGAACCGGGTCGACTGGACCATCGTGCACTACAACCCGCCGGGATCGTTGACCCTCAAC
GGTGTCGGCAAGGGTGGGGTCCGGGTCAAGCTGATGGCCAAGATCACGCCGGCCGAAGCGGGTTCGAACGTGGCGTTCGA
CATCCACCTCGGCGGTCCGGCTCTGTTCGGCCCCATCGGCATGGTGGTGGCGGCCGCACTGCGGTCCGACATCCACCACT
CGCTGGAGAAGTTCAAAGCGCTGTTCGCATCGGTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9057.44 Da
• Isoelectric Point: 5.1088

>AT144497 WP_103178029.1 NZ_CP046557:544608-544850 [Leclercia sp. 1106151]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTVTVSDSEDELIRTVRERLANPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT144497 NZ_CP062008:766056-766268 [Mycolicibacterium mucogenicum DSM 44124]
ATGGGATTTCTGGACAAGGTGAAGGACCTGGCGGCGCAGAACGCCGACAAGGTCGAGGCCGCTATCGAGAAGGTCGGCGA
CATCGTCGACGAGAAGACCGAAGGCAAGTTCAAGGGCGTTGTCGACAGCGCTCAGGAGGCGGCGAAGAAGGCCGTCGCAG
GGGACCAGCCTGCCGCTGAGGCTCCTGCCGAGGGGACGCAAGAACAGCAGTAG