Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 351329..352082 Replicon chromosome
Accession NZ_CP046557
Organism Leclercia sp. 1106151

Toxin (Protein)


Gene name yeeV Uniprot ID R8WN26
Locus tag GNG29_RS01650 Protein ID WP_016154457.1
Coordinates 351329..351706 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag GNG29_RS01655 Protein ID WP_162838704.1
Coordinates 351756..352082 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNG29_RS01610 346466..347392 - 927 WP_103177927.1 hypothetical protein -
GNG29_RS01615 347623..349047 + 1425 WP_156653757.1 DUF4832 domain-containing protein -
GNG29_RS01630 349434..349670 - 237 WP_016154458.1 hypothetical protein -
GNG29_RS01635 349682..350527 - 846 Protein_314 DUF4942 domain-containing protein -
GNG29_RS01640 350608..350811 - 204 WP_009652505.1 DUF957 domain-containing protein -
GNG29_RS01645 350841..351332 - 492 WP_009652438.1 hypothetical protein -
GNG29_RS01650 351329..351706 - 378 WP_016154457.1 TA system toxin CbtA family protein Toxin
GNG29_RS01655 351756..352082 - 327 WP_162838704.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GNG29_RS01660 352139..352360 - 222 WP_009652392.1 DUF987 domain-containing protein -
GNG29_RS01665 352374..352856 - 483 WP_016154455.1 DNA repair protein RadC -
GNG29_RS01670 352868..353086 - 219 WP_009652503.1 hypothetical protein -
GNG29_RS01675 353097..353558 - 462 WP_045890390.1 antirestriction protein -
GNG29_RS01680 353587..353841 - 255 WP_009652519.1 hypothetical protein -
GNG29_RS01685 353841..354659 - 819 WP_009652424.1 DUF945 domain-containing protein -
GNG29_RS01690 354763..354996 - 234 WP_009652474.1 DUF905 domain-containing protein -
GNG29_RS01695 355052..355273 - 222 WP_009652443.1 hypothetical protein -
GNG29_RS01700 355356..355868 - 513 WP_009652395.1 DUF4234 domain-containing protein -
GNG29_RS01705 355917..356387 - 471 WP_009652431.1 hypothetical protein -
GNG29_RS01710 356434..356745 - 312 WP_009652410.1 hypothetical protein -
GNG29_RS01715 356758..357024 - 267 WP_009652486.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14168.19 Da        Isoelectric Point: 9.5224

>T144496 WP_016154457.1 NZ_CP046557:c351706-351329 [Leclercia sp. 1106151]
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP

Download         Length: 378 bp

>T144496 NZ_CP062006:970319-970921 [Brevundimonas pondensis]
ATGACCCACATCGGCAACCTTGACGAGATTCTCGCAAAGGGCGCCTTGAGTTCTACCGCACGCCTGCAGGCTGCTGACGC
GCGGTATAACAATATCGCCTACAGCTCGATCCAGGCGCAGCGTGCAGCGCGGCAGGTCCCGTGCGGTCCTGGCGGCTGTC
TGCACGATTACGTGCCCTTCTATTTCACGACGCGCAGCCCGATGCTCTACACCATCCATCGTGGCAACGTGCCGTGCGAG
GGAGGGCAGGGCGCGCTGGTGCACCTGGTGTCGACCGCCCAGAAGGTCGTGGAAGCCGGCCTGGGCTTCGCGTTTACCGA
CGGTCACGGAATCATGACCTACTCCAGCTTCTTTGACGATCTGGGGCGGCTGGGGGAGGTCGACTGGGATGTGGTCGGCA
GTCGACAATGGGCTGATACGCTGGAGGACGGCGACCGCAAACGCCGCAAGCAGGCCGAGTTTCTCGTGCGGGACGCATTC
CCGGTTACGCTTCTCAGCGGCTTGGCGGTGCAGTCCGCGGCTCGCAAAGCCGAAGTCGAGGCTCTTCTGGAGCGCCGAGG
CGTTAGAATGAAAGTGGTGGAAAAATCCGCCTGGTACTACTAG

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12079.85 Da        Isoelectric Point: 6.6283

>AT144496 WP_162838704.1 NZ_CP046557:c352082-351756 [Leclercia sp. 1106151]
IAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELNPRHQHCVTLYA
KGLICEADSLGSHGYVYLAIYPTPATTE

Download         Length: 327 bp

>AT144496 NZ_CP062006:970932-971981 [Brevundimonas pondensis]
ATGATCACCTTCTCGAAAGGCGACCTGCTCCAGTCCGGCGCCGAGGCCGTCATTAATACGGTCAACTGCGTCGGGGTGAT
GGGCAAGGGTATCGCCCTGCAGTTCAAGCAGGCCTTCCCCCGCAACTATGATGCGTACCGGCGCGCCTGCGACGCGGGCG
AAGTACGTCTGGGCGAGATGTTCGTCTTCGATACCGGAAGCATGATCAATCCGCGCTGGATCATCAACTTTCCGACCAAG
GGTCACTGGAAGGCGAAATCCCGCCTGTCCGACATCGAGACCGGCCTTGAGGATCTGAAGCGAGTGATCCTCGAGAATGG
AATTCGCTCGATCGCCGTGCCGCCGCTCGGATGCGGCAATGGCGGTCTGGACTGGGCTGAGGTTGAGCCTGTGATCCGCC
GCGCCCTGGGCGACCTCAATGAAGTGGATGTTCGGCTCTTCGCTCCTGGAGCAGCGCCGAAAGTCGATGAGATGAGAGTG
GGTACGACCCGCCCCAACATGAGCCGTGGACGAGCGCTCGTGCTGACGCTTCTGGGTCTCTATGGGGCAGCGGGTTACCG
CCATAGCCTCCTTGAGGTGCAGAAGCTGACCTACTTCCTGCAAGCGGCGGGCGAGGATCTCAAGCTGGGCTTCCAGAAGT
ACCAGTACGGCCCCTACGCCGAGAATCTCAATCACGTGCTTCAGCGGATCGAGGGGCACTTCATTCGAGGGTACGGCGAT
CGCAGCCAAGCGGCGGAGATCGCTGTACTGGAAGGCGGCCGTAGGGAAGCCGAGGCCTACCTCGCCGGCGATGAAGCCGC
CCGGGATCGTCTCGACCGCGTGGCCGAGCTCATCGCGGGTTTCGAGACCCCCTACGGTCTCGAACTCCTGTCTACCGTCC
ACTGGGTCCTGGTTCATGACGCCGAAGCGTCCGGCGACCCGGATCGCGTGGTTCAGGCTGTGCACGCCTGGAATTCTCGG
AAGGCCGCTGTGATGCGAGAGCCTCACATCCGCACGGCGCTCGATCATCTCCAGCGGAATGGTTGGGCGAACCGGGCGCA
CGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8WN26

Antitoxin

Source ID Structure

References