Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 52410..53072 Replicon chromosome
Accession NZ_CP046557
Organism Leclercia sp. 1106151

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GNG29_RS00260 Protein ID WP_156653663.1
Coordinates 52674..53072 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GNG29_RS00255 Protein ID WP_156653662.1
Coordinates 52410..52670 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNG29_RS00225 47427..47741 - 315 WP_103177669.1 PTS sugar transporter subunit IIB -
GNG29_RS00230 48036..48983 + 948 WP_103177670.1 LacI family transcriptional regulator -
GNG29_RS00235 49020..49316 - 297 WP_103177671.1 hypothetical protein -
GNG29_RS00240 49639..50058 + 420 WP_156653659.1 GNAT family N-acetyltransferase -
GNG29_RS00245 50055..50714 - 660 WP_156653660.1 TetR family transcriptional regulator -
GNG29_RS00250 50793..52292 + 1500 WP_156653661.1 MFS transporter -
GNG29_RS00255 52410..52670 + 261 WP_156653662.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GNG29_RS00260 52674..53072 + 399 WP_156653663.1 PIN domain-containing protein Toxin
GNG29_RS00265 53267..54070 + 804 WP_156653664.1 lipoprotein NlpA -
GNG29_RS00270 54198..54977 + 780 WP_156653665.1 MBL fold metallo-hydrolase -
GNG29_RS00275 55003..55965 + 963 WP_156653666.1 helix-turn-helix domain-containing protein -
GNG29_RS00280 55985..57073 - 1089 WP_156653667.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14665.76 Da        Isoelectric Point: 5.4732

>T144494 WP_156653663.1 NZ_CP046557:52674-53072 [Leclercia sp. 1106151]
MLHMLDTNIVSHLVRQHPGVVNHYSRLAPEDMCISSVTEAELLYGVAKKQSLRLHETISEFLKTITVCDWDSDAAAIYGK
LRAEMEKHGKVMGDLDQLIAAHAISRGTTIVTNDQAFAMVQELTVEDWTTAA

Download         Length: 399 bp

>T144494 NZ_CP061979:58742-59047 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10222.60 Da        Isoelectric Point: 9.8083

>AT144494 WP_156653662.1 NZ_CP046557:52410-52670 [Leclercia sp. 1106151]
MERKAKLFKKGRNQAVLLPAEFAFDAESVWIRRDEEGNVVLRAMSEKERHRENFLRLLKQTHVPDSFLSKEERNQSYTTR
DPFEGL

Download         Length: 261 bp

>AT144494 NZ_CP061979:58522-58740 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References