Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 348149..348630 Replicon chromosome
Accession NZ_CP046539
Organism Escherichia coli strain FHI_NMBU_10

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7YS45
Locus tag GOE21_RS01625 Protein ID WP_014966210.1
Coordinates 348149..348439 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A0P7NPJ2
Locus tag GOE21_RS01630 Protein ID WP_000100895.1
Coordinates 348439..348630 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOE21_RS01595 343342..343545 - 204 WP_000096347.1 DUF4224 domain-containing protein -
GOE21_RS01600 343604..346048 - 2445 WP_044809020.1 exonuclease -
GOE21_RS01605 346141..346329 - 189 WP_033885206.1 DUF1482 family protein -
GOE21_RS01610 346326..346514 - 189 WP_000449173.1 cell division inhibitor -
GOE21_RS01615 347316..347717 - 402 WP_096853748.1 hypothetical protein -
GOE21_RS01620 347729..347881 - 153 WP_062863539.1 DUF1391 family protein -
GOE21_RS01625 348149..348439 - 291 WP_014966210.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GOE21_RS01630 348439..348630 - 192 WP_000100895.1 hypothetical protein Antitoxin
GOE21_RS01635 348648..349148 - 501 WP_000824162.1 helix-turn-helix transcriptional regulator -
GOE21_RS01640 349256..349531 + 276 WP_042969575.1 helix-turn-helix domain-containing protein -
GOE21_RS01645 349515..349940 + 426 WP_000693925.1 Rha family transcriptional regulator -
GOE21_RS01650 350009..351046 + 1038 WP_062863540.1 hypothetical protein -
GOE21_RS01655 350958..351500 + 543 WP_072130322.1 replication protein -
GOE21_RS01660 351534..352250 + 717 WP_062871713.1 DUF1627 domain-containing protein -
GOE21_RS01665 352283..352564 + 282 WP_062877284.1 hypothetical protein -
GOE21_RS01670 352561..352866 + 306 WP_044808070.1 DUF4406 domain-containing protein -
GOE21_RS01675 353014..353196 + 183 WP_001224672.1 hypothetical protein -
GOE21_RS01680 353189..353365 + 177 WP_000753060.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 340836..390231 49395


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11176.05 Da        Isoelectric Point: 9.9854

>T144470 WP_014966210.1 NZ_CP046539:c348439-348149 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTASNIE
IVNVVHSRRQYPNKTC

Download         Length: 291 bp

>T144470 NZ_CP061970:1986472-1986574 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7003.80 Da        Isoelectric Point: 4.0270

>AT144470 WP_000100895.1 NZ_CP046539:c348630-348439 [Escherichia coli]
MSTALSPIISEFETVEQENSYNEWLRAKVAASLSDPRPAIPHDEVMAEMENLIAQLAATNRSE

Download         Length: 192 bp

>AT144470 NZ_CP061970:c1986581-1986436 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7YS45

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7NPJ2

References