Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 1370075..1370594 Replicon chromosome
Accession NZ_CP046532
Organism Mannheimia sp. ZY171111

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GM698_RS06595 Protein ID WP_209289139.1
Coordinates 1370328..1370594 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag GM698_RS06590 Protein ID WP_159628595.1
Coordinates 1370075..1370341 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GM698_RS06570 (GM698_06525) 1365753..1366922 + 1170 WP_176807431.1 HlyD family efflux transporter periplasmic adaptor subunit -
GM698_RS06575 (GM698_06530) 1367197..1368591 - 1395 WP_176811944.1 GTPase HflX -
GM698_RS06580 (GM698_06535) 1368612..1368887 - 276 WP_159628596.1 RNA chaperone Hfq -
GM698_RS06585 (GM698_06540) 1368958..1369911 - 954 WP_176812811.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -
GM698_RS06590 (GM698_06545) 1370075..1370341 + 267 WP_159628595.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GM698_RS06595 (GM698_06550) 1370328..1370594 + 267 WP_209289139.1 type II toxin-antitoxin system YafQ family toxin Toxin
GM698_RS06600 (GM698_06555) 1370619..1372511 - 1893 WP_209289140.1 DNA mismatch repair endonuclease MutL -
GM698_RS06605 (GM698_06560) 1372631..1373869 + 1239 WP_209289141.1 glutamate-5-semialdehyde dehydrogenase -
GM698_RS06610 (GM698_06565) 1373871..1374716 + 846 WP_176807426.1 virulence factor BrkB family protein -
GM698_RS06615 (GM698_06570) 1374691..1375125 + 435 WP_176811939.1 D-aminoacyl-tRNA deacylase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-88)

Antitoxin

(1-84)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10310.81 Da        Isoelectric Point: 5.6184

>T144465 WP_209289139.1 NZ_CP046532:1370328-1370594 [Mannheimia sp. ZY171111]
MREIEYSNAFKRDYEKCAVDTLSSSLIEALYFLINDKPLPEKYCDHALTGEWKGFRDCHIQPDLVLIYRKIDDKLELLRI
GSHSNLFG

Download         Length: 267 bp

>T144465 NZ_CP061970:323014-323382 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9704.13 Da        Isoelectric Point: 4.7863

>AT144465 WP_159628595.1 NZ_CP046532:1370075-1370341 [Mannheimia sp. ZY171111]
MANSALVSVRISPEIKEQASEVLAGIGLTVSDVMRMTLAKIATEKRFQFDYQPNVETAEVLKAVRNGDEKLNPAKNIADL
MEQLNARD

Download         Length: 267 bp

>AT144465 NZ_CP061970:322796-323017 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References