Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-dinJ/YafQ-RelB |
Location | 1370075..1370594 | Replicon | chromosome |
Accession | NZ_CP046532 | ||
Organism | Mannheimia sp. ZY171111 |
Toxin (Protein)
Gene name | relE | Uniprot ID | - |
Locus tag | GM698_RS06595 | Protein ID | WP_209289139.1 |
Coordinates | 1370328..1370594 (+) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | dinJ | Uniprot ID | - |
Locus tag | GM698_RS06590 | Protein ID | WP_159628595.1 |
Coordinates | 1370075..1370341 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GM698_RS06570 (GM698_06525) | 1365753..1366922 | + | 1170 | WP_176807431.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
GM698_RS06575 (GM698_06530) | 1367197..1368591 | - | 1395 | WP_176811944.1 | GTPase HflX | - |
GM698_RS06580 (GM698_06535) | 1368612..1368887 | - | 276 | WP_159628596.1 | RNA chaperone Hfq | - |
GM698_RS06585 (GM698_06540) | 1368958..1369911 | - | 954 | WP_176812811.1 | tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA | - |
GM698_RS06590 (GM698_06545) | 1370075..1370341 | + | 267 | WP_159628595.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
GM698_RS06595 (GM698_06550) | 1370328..1370594 | + | 267 | WP_209289139.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
GM698_RS06600 (GM698_06555) | 1370619..1372511 | - | 1893 | WP_209289140.1 | DNA mismatch repair endonuclease MutL | - |
GM698_RS06605 (GM698_06560) | 1372631..1373869 | + | 1239 | WP_209289141.1 | glutamate-5-semialdehyde dehydrogenase | - |
GM698_RS06610 (GM698_06565) | 1373871..1374716 | + | 846 | WP_176807426.1 | virulence factor BrkB family protein | - |
GM698_RS06615 (GM698_06570) | 1374691..1375125 | + | 435 | WP_176811939.1 | D-aminoacyl-tRNA deacylase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10310.81 Da Isoelectric Point: 5.6184
>T144465 WP_209289139.1 NZ_CP046532:1370328-1370594 [Mannheimia sp. ZY171111]
MREIEYSNAFKRDYEKCAVDTLSSSLIEALYFLINDKPLPEKYCDHALTGEWKGFRDCHIQPDLVLIYRKIDDKLELLRI
GSHSNLFG
MREIEYSNAFKRDYEKCAVDTLSSSLIEALYFLINDKPLPEKYCDHALTGEWKGFRDCHIQPDLVLIYRKIDDKLELLRI
GSHSNLFG
Download Length: 267 bp
>T144465 NZ_CP061970:323014-323382 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9704.13 Da Isoelectric Point: 4.7863
>AT144465 WP_159628595.1 NZ_CP046532:1370075-1370341 [Mannheimia sp. ZY171111]
MANSALVSVRISPEIKEQASEVLAGIGLTVSDVMRMTLAKIATEKRFQFDYQPNVETAEVLKAVRNGDEKLNPAKNIADL
MEQLNARD
MANSALVSVRISPEIKEQASEVLAGIGLTVSDVMRMTLAKIATEKRFQFDYQPNVETAEVLKAVRNGDEKLNPAKNIADL
MEQLNARD
Download Length: 267 bp
>AT144465 NZ_CP061970:322796-323017 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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