Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1310132..1310763 Replicon chromosome
Accession NZ_CP046532
Organism Mannheimia sp. ZY171111

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GM698_RS06385 Protein ID WP_176807449.1
Coordinates 1310365..1310763 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GM698_RS06380 Protein ID WP_176807450.1
Coordinates 1310132..1310365 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GM698_RS06355 (GM698_06310) 1305610..1306812 - 1203 WP_209289115.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
GM698_RS06360 (GM698_06315) 1306970..1307662 + 693 WP_176807453.1 DNA repair protein RadC -
GM698_RS06365 (GM698_06320) 1307833..1308069 + 237 WP_006251446.1 50S ribosomal protein L28 -
GM698_RS06370 (GM698_06325) 1308081..1308251 + 171 WP_159628615.1 50S ribosomal protein L33 -
GM698_RS06375 (GM698_06330) 1308599..1309963 + 1365 WP_176809330.1 diaminobutyrate--2-oxoglutarate transaminase -
GM698_RS06380 (GM698_06335) 1310132..1310365 + 234 WP_176807450.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GM698_RS06385 (GM698_06340) 1310365..1310763 + 399 WP_176807449.1 tRNA(fMet)-specific endonuclease VapC Toxin
GM698_RS06390 (GM698_06345) 1310783..1312318 + 1536 WP_209289116.1 L-2,4-diaminobutyrate decarboxylase -
GM698_RS06395 (GM698_06350) 1312379..1312954 - 576 WP_209289117.1 NAD(P)H-dependent oxidoreductase -
GM698_RS06400 (GM698_06355) 1313123..1313647 + 525 WP_176808965.1 ferredoxin-type protein NapF -
GM698_RS06405 (GM698_06360) 1313663..1313929 + 267 WP_176807446.1 chaperone NapD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14891.17 Da        Isoelectric Point: 8.0586

>T144464 WP_176807449.1 NZ_CP046532:1310365-1310763 [Mannheimia sp. ZY171111]
MLKYMLDSNIVIYVIKHRPVEVLQRFNQNAGKMCVSSITAAELYYGAEKSGFSARNIAVIEDFLSRLTILDYQPKSAAHF
GNIKAELAKQGKLIGENDIHIAAHARSEGLVIVTNNLREFERVEGLRLENWV

Download         Length: 399 bp

>T144464 NZ_CP061966:c129010-128594 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCTGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9009.22 Da        Isoelectric Point: 4.3094

>AT144464 WP_176807450.1 NZ_CP046532:1310132-1310365 [Mannheimia sp. ZY171111]
MIEASIFMTNRSQAVRLPAEVRFDNDVKKIAVRILGNERILSPLNQSWDSFFLNSETVSEDFMVEREIAMQPEREDF

Download         Length: 234 bp

>AT144464 NZ_CP061966:c129237-129007 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAAGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References