Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 117121..117677 Replicon chromosome
Accession NZ_CP046532
Organism Mannheimia sp. ZY171111

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GM698_RS00555 Protein ID WP_176812491.1
Coordinates 117357..117677 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GM698_RS00550 Protein ID WP_176812492.1
Coordinates 117121..117360 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GM698_RS00535 (GM698_00535) 112443..113486 + 1044 WP_176812495.1 polysulfide reductase NrfD -
GM698_RS00540 (GM698_00540) 113538..115493 - 1956 WP_176812494.1 DUF2075 domain-containing protein -
GM698_RS00545 (GM698_00545) 115508..116800 - 1293 WP_176812493.1 ATP-binding protein -
GM698_RS00550 (GM698_00550) 117121..117360 + 240 WP_176812492.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GM698_RS00555 (GM698_00555) 117357..117677 + 321 WP_176812491.1 endoribonuclease MazF Toxin
GM698_RS00560 (GM698_00560) 117674..118621 + 948 WP_209289466.1 hypothetical protein -
GM698_RS00565 (GM698_00565) 118618..120309 + 1692 WP_176812489.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-101)

Antitoxin

Antitoxin PemI-like

(1-78)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11801.86 Da        Isoelectric Point: 8.4983

>T144462 WP_176812491.1 NZ_CP046532:117357-117677 [Mannheimia sp. ZY171111]
MSEYVPDVGDIIWLNFTPQAGHRPVVVLTPASYNQLTSLLICCPLTTKIKGYPFEVHIAGKPQNVVLSDQVKSLDWRVRQ
AEFKGKIAESELVEIRKKVGVLLGLV

Download         Length: 321 bp

>T144462 NZ_CP061965:c4874383-4873466 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8748.05 Da        Isoelectric Point: 4.5125

>AT144462 WP_176812492.1 NZ_CP046532:117121-117360 [Mannheimia sp. ZY171111]
MQLAIKKWGNSVGVRIPASILTALQLQADNLVDIRAENGKIIIEPIRQEYSLEQLLSGITAENLHQEIETGEPIGKEQL

Download         Length: 240 bp

>AT144462 NZ_CP061965:c4875147-4874389 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTTGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References