Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3713389..3714063 Replicon chromosome
Accession NZ_CP046529
Organism Mycobacterium tuberculosis strain SIT745/EAI1-MYS

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag AYJ03_RS17570 Protein ID WP_003417282.1
Coordinates 3713389..3713817 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag AYJ03_RS17575 Protein ID WP_003417286.1
Coordinates 3713821..3714063 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYJ03_RS17545 3709211..3709612 - 402 WP_003417264.1 cytidine deaminase -
AYJ03_RS17550 3709753..3710187 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
AYJ03_RS17555 3710184..3710618 + 435 WP_009936281.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
AYJ03_RS17560 3710747..3712519 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
AYJ03_RS17565 3712519..3713310 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
AYJ03_RS17570 3713389..3713817 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
AYJ03_RS17575 3713821..3714063 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
AYJ03_RS17580 3714185..3714799 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
AYJ03_RS17585 3714796..3715461 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
AYJ03_RS17590 3715462..3715995 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
AYJ03_RS17595 3715992..3716081 - 90 WP_009934953.1 pterin-4-alpha-carbinolamine dehydratase moaB3 -
AYJ03_RS17600 3716142..3717854 + 1713 WP_003905037.1 IS110 family transposase -
AYJ03_RS17605 3717787..3718725 - 939 WP_009935306.1 sigma-70 family RNA polymerase sigma factor SigJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T144457 WP_003417282.1 NZ_CP046529:c3713817-3713389 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T144457 NZ_CP061965:c4236118-4235708 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT144457 WP_003417286.1 NZ_CP046529:c3714063-3713821 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT144457 NZ_CP061965:c4236365-4236099 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References