144453

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 3142643..3143247 Replicon chromosome
Accession NZ_CP046529
Organism Mycobacterium tuberculosis strain SIT745/EAI1-MYS

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag AYJ03_RS14910 Protein ID WP_003414492.1
Coordinates 3142643..3143035 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P71622
Locus tag AYJ03_RS14915 Protein ID WP_003912003.1
Coordinates 3143032..3143247 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYJ03_RS14880 3137793..3138581 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
AYJ03_RS14885 3138915..3139460 - 546 WP_003913758.1 DUF1802 family protein -
AYJ03_RS14890 3139732..3140616 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
AYJ03_RS14895 3140619..3141506 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin -
AYJ03_RS14900 3141811..3142356 - 546 WP_003899500.1 DUF1802 family protein -
AYJ03_RS14905 3142353..3142622 - 270 WP_003414489.1 DUF2277 family protein -
AYJ03_RS14910 3142643..3143035 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
AYJ03_RS14915 3143032..3143247 - 216 WP_003912003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AYJ03_RS14920 3143294..3144043 + 750 WP_003414497.1 enoyl-CoA hydratase -
AYJ03_RS14925 3144122..3145204 - 1083 WP_003414499.1 ABC transporter ATP-binding protein -
AYJ03_RS14930 3145197..3146507 - 1311 WP_003414501.1 ABC transporter substrate-binding protein -
AYJ03_RS14935 3146510..3147337 - 828 WP_003414504.1 carbohydrate ABC transporter permease -
AYJ03_RS14940 3147334..3148245 - 912 WP_003414505.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T144453 WP_003414492.1 NZ_CP046529:c3143035-3142643 [Mycobacterium tuberculosis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T144453 NZ_CP061965:c1062433-1062215 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7483.50 Da        Isoelectric Point: 4.9732

>AT144453 WP_003912003.1 NZ_CP046529:c3143247-3143032 [Mycobacterium tuberculosis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAADDDELFTTGVSWNVS

Download         Length: 216 bp

>AT144453 NZ_CP061965:c1062834-1062460 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8

Antitoxin

Source ID Structure
AlphaFold DB P71622

References