144451

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3114924..3115494 Replicon chromosome
Accession NZ_CP046529
Organism Mycobacterium tuberculosis strain SIT745/EAI1-MYS

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag AYJ03_RS14765 Protein ID WP_003414166.1
Coordinates 3114924..3115280 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag AYJ03_RS14770 Protein ID WP_003901465.1
Coordinates 3115264..3115494 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYJ03_RS14745 3110376..3112064 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
AYJ03_RS14750 3112068..3112394 - 327 WP_003414157.1 hypothetical protein -
AYJ03_RS14755 3112567..3113154 + 588 WP_003914429.1 DUF3558 family protein -
AYJ03_RS14760 3113173..3114822 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
AYJ03_RS14765 3114924..3115280 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
AYJ03_RS14770 3115264..3115494 - 231 WP_003901465.1 antitoxin MazE Antitoxin
AYJ03_RS14775 3115537..3116580 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
AYJ03_RS14780 3116771..3117046 + 276 WP_003911993.1 DUF1778 domain-containing protein -
AYJ03_RS14785 3117222..3117476 - 255 WP_003917684.1 hypothetical protein -
AYJ03_RS14790 3117624..3118028 + 405 WP_009938577.1 hypothetical protein -
AYJ03_RS14795 3118025..3118216 + 192 WP_003414184.1 hypothetical protein -
AYJ03_RS14800 3118280..3119569 + 1290 Protein_2903 transposase family protein -
AYJ03_RS14805 3119803..3120060 + 258 WP_003899489.1 hypothetical protein -
AYJ03_RS14810 3120165..3120476 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T144451 WP_003414166.1 NZ_CP046529:c3115280-3114924 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

>T144451 NZ_CP061965:332472-332840 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT144451 WP_003901465.1 NZ_CP046529:c3115494-3115264 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT144451 NZ_CP061965:332254-332475 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGAGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FBW3

References