144444

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2874265..2874974 Replicon chromosome
Accession NZ_CP046529
Organism Mycobacterium tuberculosis strain SIT745/EAI1-MYS

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag AYJ03_RS13440 Protein ID WP_003413164.1
Coordinates 2874265..2874678 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag AYJ03_RS13445 Protein ID WP_003413167.1
Coordinates 2874717..2874974 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYJ03_RS13410 2869318..2870523 - 1206 WP_003413027.1 chorismate synthase -
AYJ03_RS13415 2870631..2870945 + 315 WP_009937839.1 hypothetical protein -
AYJ03_RS13420 2871241..2872452 + 1212 WP_009936235.1 alpha/beta hydrolase family protein -
AYJ03_RS13425 2872579..2873238 + 660 WP_003900846.1 LppA family lipoprotein -
AYJ03_RS13430 2873235..2873897 + 663 WP_003900848.1 hypothetical protein -
AYJ03_RS13435 2873894..2874172 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
AYJ03_RS13440 2874265..2874678 + 414 WP_003413164.1 PIN domain nuclease Toxin
AYJ03_RS13445 2874717..2874974 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
AYJ03_RS13450 2874971..2875348 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
AYJ03_RS13455 2875364..2875738 - 375 WP_003413177.1 hypothetical protein -
AYJ03_RS13460 2875838..2876233 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
AYJ03_RS13465 2876230..2876475 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
AYJ03_RS13470 2876886..2877305 - 420 WP_003413190.1 A24 family peptidase -
AYJ03_RS13475 2877317..2878126 - 810 WP_003413193.1 shikimate dehydrogenase -
AYJ03_RS13480 2878123..2879376 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
AYJ03_RS13485 2879369..2879881 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T144444 WP_003413164.1 NZ_CP046529:2874265-2874678 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T144444 NZ_CP061961:c4750804-4750463 [Klebsiella pneumoniae]
ATGAAAACCTTACCTGCAACAATTCAGCGGGCGGCTAAGCCGTGCCCGTCTCCCGTGACGGTCTGGCAGATGCTGCTTAC
CCGTCTGCTGGAGCAACATTATGGCCTTACCCTGAATGACACGCCGTTCAGCGATGAAACCGTTATTCAGGAACATATCA
ACGCAGGCATCACACTGGTTGATGCCGTTAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCGCAGAGGGTTT
AACTGTCAGGAACAGTCACCTTATCTGGGCGCAGTGGATATTTTGCGGGCGCGGCAGGCAACCGGCCTGTTACGGCAAAG
ACATCTTCCTTCGATACGCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT144444 WP_003413167.1 NZ_CP046529:2874717-2874974 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT144444 NZ_CP061961:c4751154-4750828 [Klebsiella pneumoniae]
ATGCCACTGACTGATGCCATACAGTGGGGATTAAAGCGAAGTTTCACACCGAATTTTGGCGCAAGGCTGGTACAGGAAGG
CAACCGACTGCACTACCTGGCTGACCGGGCCAATATCACCGGTAAATTTGGTGACGCCGAATGTCTGAAGCTGGAAGAAG
CATTCCCGCATTTTATCCGCCAGATGGAACTGATGCTGAGCACTGGCGAACTTAATCCCCGTCATGCGCACAGCGTCACT
CTCTACCACAACGCTTTCACCTGTGAAGCCGATACTCTCGGTAGTTGTGGTTACGTCTACATCGTTATTTATCCCACTCA
ACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References