144441

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2410832..2411361 Replicon chromosome
Accession NZ_CP046529
Organism Mycobacterium tuberculosis strain SIT745/EAI1-MYS

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag AYJ03_RS11265 Protein ID WP_003411124.1
Coordinates 2410832..2411149 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag AYJ03_RS11270 Protein ID WP_003411127.1
Coordinates 2411146..2411361 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYJ03_RS11235 2405969..2407045 + 1077 WP_003411110.1 hypothetical protein -
AYJ03_RS11240 2407042..2407323 + 282 WP_003411112.1 hypothetical protein -
AYJ03_RS11245 2407359..2408432 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
AYJ03_RS11250 2408437..2408967 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
AYJ03_RS11255 2409015..2410361 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
AYJ03_RS11265 2410832..2411149 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AYJ03_RS11270 2411146..2411361 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
AYJ03_RS11275 2411616..2412674 + 1059 WP_003411129.1 hypothetical protein -
AYJ03_RS11280 2412804..2413160 - 357 WP_003411130.1 hypothetical protein -
AYJ03_RS11285 2413255..2414037 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
AYJ03_RS11290 2414305..2414595 - 291 WP_003900476.1 YggT family protein -
AYJ03_RS11295 2414757..2415413 - 657 WP_003411133.1 cell division protein SepF -
AYJ03_RS11300 2415479..2416255 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T144441 WP_003411124.1 NZ_CP046529:c2411149-2410832 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T144441 NZ_CP061961:c3507828-3507726 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT144441 WP_003411127.1 NZ_CP046529:c2411361-2411146 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT144441 NZ_CP061961:3507719-3507864 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References