Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
Location | 2229882..2230570 | Replicon | chromosome |
Accession | NZ_CP046529 | ||
Organism | Mycobacterium tuberculosis strain SIT745/EAI1-MYS |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P0A653 |
Locus tag | AYJ03_RS10415 | Protein ID | WP_003409958.1 |
Coordinates | 2229882..2230301 (-) | Length | 140 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P9WJ28 |
Locus tag | AYJ03_RS10420 | Protein ID | WP_003409968.1 |
Coordinates | 2230310..2230570 (-) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AYJ03_RS10395 | 2225377..2226225 | + | 849 | WP_003409942.1 | class I SAM-dependent methyltransferase | - |
AYJ03_RS10400 | 2226188..2227633 | - | 1446 | WP_003899115.1 | APC family permease | - |
AYJ03_RS10405 | 2227812..2228498 | - | 687 | WP_003409954.1 | immunoprotective protein Mpt64 | - |
AYJ03_RS10410 | 2228689..2229657 | - | 969 | WP_003899116.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
AYJ03_RS10415 | 2229882..2230301 | - | 420 | WP_003409958.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
AYJ03_RS10420 | 2230310..2230570 | - | 261 | WP_003409968.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
AYJ03_RS10425 | 2230713..2232389 | + | 1677 | WP_003899118.1 | PecA family PE domain-processing aspartic protease | - |
AYJ03_RS10430 | 2232377..2233030 | - | 654 | WP_003409976.1 | cutinase Cfp21 | - |
AYJ03_RS10435 | 2233145..2233375 | + | 231 | WP_003409980.1 | DUF167 domain-containing protein | - |
AYJ03_RS10440 | 2233460..2234371 | - | 912 | WP_003409986.1 | ArgP/LysG family DNA-binding transcriptional regulator | - |
AYJ03_RS10445 | 2234480..2235079 | + | 600 | WP_003409989.1 | L-lysine exporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 14724.89 Da Isoelectric Point: 7.9535
>T144435 WP_003409958.1 NZ_CP046529:c2230301-2229882 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA
Download Length: 420 bp
>T144435 NZ_CP061960:90138-90296 [Klebsiella pneumoniae]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG
Antitoxin
Download Length: 87 a.a. Molecular weight: 9528.88 Da Isoelectric Point: 5.1007
>AT144435 WP_003409968.1 NZ_CP046529:c2230570-2230310 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV
Download Length: 261 bp
>AT144435 NZ_CP061960:90027-90092 [Klebsiella pneumoniae]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829C4H9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829C483 |