144434

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2208149..2208693 Replicon chromosome
Accession NZ_CP046529
Organism Mycobacterium tuberculosis strain SIT745/EAI1-MYS

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag AYJ03_RS10295 Protein ID WP_003409896.1
Coordinates 2208149..2208445 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag AYJ03_RS10300 Protein ID WP_003409899.1
Coordinates 2208442..2208693 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYJ03_RS10240 2203182..2203532 - 351 WP_003899096.1 hypothetical protein -
AYJ03_RS10245 2203543..2204445 - 903 WP_003899097.1 hypothetical protein -
AYJ03_RS10250 2204466..2204657 - 192 WP_003409876.1 hypothetical protein -
AYJ03_RS10255 2204658..2204954 - 297 WP_003409877.1 hypothetical protein -
AYJ03_RS10260 2205194..2205409 + 216 WP_003409878.1 antitoxin -
AYJ03_RS10265 2205406..2205717 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
AYJ03_RS20770 2205691..2206212 - 522 WP_003904745.1 hypothetical protein -
AYJ03_RS10275 2206187..2206564 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
AYJ03_RS10280 2206606..2207055 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
AYJ03_RS10285 2207052..2207597 + 546 WP_003409891.1 SecB-like chaperone -
AYJ03_RS10290 2207486..2208100 - 615 WP_003901296.1 hypothetical protein -
AYJ03_RS10295 2208149..2208445 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AYJ03_RS10300 2208442..2208693 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
AYJ03_RS10305 2208680..2209174 + 495 WP_003899099.1 hypothetical protein -
AYJ03_RS10310 2209334..2209741 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
AYJ03_RS10315 2209745..2210017 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
AYJ03_RS10320 2210050..2211270 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
AYJ03_RS10325 2212169..2212966 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T144434 WP_003409896.1 NZ_CP046529:c2208445-2208149 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T144434 NZ_CP061960:68826-68975 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT144434 WP_003409899.1 NZ_CP046529:c2208693-2208442 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT144434 NZ_CP061960:c68781-68722 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References