144430

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1946040..1946653 Replicon chromosome
Accession NZ_CP046529
Organism Mycobacterium tuberculosis strain SIT745/EAI1-MYS

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag AYJ03_RS09070 Protein ID WP_003408465.1
Coordinates 1946040..1946429 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag AYJ03_RS09075 Protein ID WP_003408469.1
Coordinates 1946426..1946653 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYJ03_RS09040 1941669..1942583 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
AYJ03_RS09045 1942586..1943416 + 831 WP_003916848.1 cyclase family protein -
AYJ03_RS09050 1943416..1943766 + 351 WP_003898986.1 cupin domain-containing protein -
AYJ03_RS09055 1943819..1944637 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
AYJ03_RS09060 1944651..1945430 + 780 WP_003408460.1 IclR family transcriptional regulator -
AYJ03_RS09070 1946040..1946429 - 390 WP_003408465.1 PIN domain-containing protein Toxin
AYJ03_RS09075 1946426..1946653 - 228 WP_003408469.1 antitoxin Antitoxin
AYJ03_RS09080 1946871..1948355 + 1485 WP_003408473.1 carboxylase -
AYJ03_RS09085 1948352..1949599 + 1248 WP_003408476.1 serine hydrolase -
AYJ03_RS09090 1949642..1950061 - 420 WP_003408483.1 hypothetical protein -
AYJ03_RS09095 1950051..1950761 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T144430 WP_003408465.1 NZ_CP046529:c1946429-1946040 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T144430 NZ_CP061957:c4880196-4879912 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT144430 WP_003408469.1 NZ_CP046529:c1946653-1946426 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT144430 NZ_CP061957:c4880428-4880186 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAN9

References