144417

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 755664..756352 Replicon chromosome
Accession NZ_CP046529
Organism Mycobacterium tuberculosis strain SIT745/EAI1-MYS

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag AYJ03_RS03490 Protein ID WP_003403386.1
Coordinates 755664..756101 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O06777
Locus tag AYJ03_RS03495 Protein ID WP_003911263.1
Coordinates 756098..756352 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYJ03_RS03460 751915..752925 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
AYJ03_RS03465 753313..753696 - 384 WP_003403365.1 ribonuclease VapC6 -
AYJ03_RS03470 753791..753946 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
AYJ03_RS03475 754022..754738 - 717 WP_010886082.1 CPBP family intramembrane metalloprotease -
AYJ03_RS03480 755014..755322 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
AYJ03_RS03485 755309..755554 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
AYJ03_RS03490 755664..756101 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
AYJ03_RS03495 756098..756352 - 255 WP_003911263.1 antitoxin VapB7 Antitoxin
AYJ03_RS03500 756466..758829 + 2364 WP_003898547.1 arylsulfatase AtsD -
AYJ03_RS03505 758892..759218 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
AYJ03_RS03510 759130..759468 + 339 WP_003403405.1 PIN domain-containing protein -
AYJ03_RS03515 759465..759638 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T144417 WP_003403386.1 NZ_CP046529:c756101-755664 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T144417 NZ_CP061952:c4800040-4799756 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.99 Da        Isoelectric Point: 11.7073

>AT144417 WP_003911263.1 NZ_CP046529:c756352-756098 [Mycobacterium tuberculosis]
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALR
ARRG

Download         Length: 255 bp

>AT144417 NZ_CP061952:c4800272-4800030 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JQG1

References