144415

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 755014..755554 Replicon chromosome
Accession NZ_CP046529
Organism Mycobacterium tuberculosis strain SIT745/EAI1-MYS

Toxin (Protein)


Gene name mazF Uniprot ID P9WII0
Locus tag AYJ03_RS03480 Protein ID WP_003403376.1
Coordinates 755014..755322 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag AYJ03_RS03485 Protein ID WP_003403381.1
Coordinates 755309..755554 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYJ03_RS03455 750329..751834 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
AYJ03_RS03460 751915..752925 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
AYJ03_RS03465 753313..753696 - 384 WP_003403365.1 ribonuclease VapC6 -
AYJ03_RS03470 753791..753946 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
AYJ03_RS03475 754022..754738 - 717 WP_010886082.1 CPBP family intramembrane metalloprotease -
AYJ03_RS03480 755014..755322 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AYJ03_RS03485 755309..755554 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
AYJ03_RS03490 755664..756101 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
AYJ03_RS03495 756098..756352 - 255 WP_003911263.1 antitoxin VapB7 -
AYJ03_RS03500 756466..758829 + 2364 WP_003898547.1 arylsulfatase AtsD -
AYJ03_RS03505 758892..759218 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
AYJ03_RS03510 759130..759468 + 339 WP_003403405.1 PIN domain-containing protein -
AYJ03_RS03515 759465..759638 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-101)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11320.10 Da        Isoelectric Point: 11.6554

>T144415 WP_003403376.1 NZ_CP046529:c755322-755014 [Mycobacterium tuberculosis]
MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRR
ITRLSPARLHEACQTLRASTGC

Download         Length: 309 bp

>T144415 NZ_CP061952:4084298-4084516 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT144415 WP_003403381.1 NZ_CP046529:c755554-755309 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT144415 NZ_CP061952:4083897-4084271 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSE5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References