Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3789369..3789847 Replicon chromosome
Accession NZ_CP046527
Organism Escherichia coli strain RM19259

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag GN312_RS18560 Protein ID WP_001303876.1
Coordinates 3789369..3789656 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag GN312_RS18565 Protein ID WP_000536233.1
Coordinates 3789656..3789847 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN312_RS18530 3784518..3786989 - 2472 WP_000034474.1 exonuclease -
GN312_RS18535 3787083..3787274 - 192 WP_001098307.1 DUF1482 family protein -
GN312_RS18540 3787271..3787459 - 189 WP_000413705.1 cell division inhibition protein DicB -
GN312_RS18545 3788033..3788218 + 186 WP_001133046.1 hypothetical protein -
GN312_RS18550 3788405..3788794 - 390 WP_000394511.1 hypothetical protein -
GN312_RS18555 3788936..3789091 - 156 WP_000379575.1 DUF1391 family protein -
GN312_RS18560 3789369..3789656 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GN312_RS18565 3789656..3789847 - 192 WP_000536233.1 hypothetical protein Antitoxin
GN312_RS18570 3789875..3790276 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
GN312_RS18575 3790385..3790657 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
GN312_RS18580 3790641..3791066 + 426 WP_000693855.1 Rha family transcriptional regulator -
GN312_RS18585 3791273..3791728 - 456 WP_000273724.1 hypothetical protein -
GN312_RS18590 3791807..3792904 + 1098 WP_001475117.1 hypothetical protein -
GN312_RS18595 3792911..3793657 + 747 WP_000788745.1 ATP-binding protein -
GN312_RS18600 3793679..3794449 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T144383 WP_001303876.1 NZ_CP046527:c3789656-3789369 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T144383 NZ_CP061941:2488185-2488463 [Marinomonas algicola]
ATGATTTTATGGGAAGAAGAATCGCTAAATGATCGTGAGAAGATCTTTGAGTTTCTTTATGACTTCAACCCTGATGCGGC
AGACAAAACTGACGAAATTATCGAAGCTAAAGTAGAAAATTTACTTGAGCAACCATTAATGGGTGTTCAACGTGATGGTA
TTCGAGGACGACTACTCATTATCCCCGAAATCTCAATGATCGTTTCTTACTGGGTTGACGGCTCAGCTATTCGCGTAATG
CGAGTTCTACACCAGAAGCAAAAATTCCCTACCGACTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT144383 WP_000536233.1 NZ_CP046527:c3789847-3789656 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT144383 NZ_CP061941:2487904-2488188 [Marinomonas algicola]
ATGGACACTCGAATTCAATTTCGTGTTGATGACGAAATCAAACGCTTAGCTCAGCAAATGGCTGAAAGCCAAGGACGCAC
ACTTAGCGATGCTTGTCGTGAACTTACTGAGCAAATGGCTGAACAACAACGCAAAGCATTATCTCACGACGCTTGGTTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCTCATTTGTTGACCATGACTCAGCAAAAGCACGA
ATGGCTGAACGAAAAGCAAAGATTCGGAGCCGAGGTCAACAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References