Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3623000..3623705 Replicon chromosome
Accession NZ_CP046527
Organism Escherichia coli strain RM19259

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag GN312_RS17820 Protein ID WP_000539519.1
Coordinates 3623319..3623705 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GN312_RS17815 Protein ID WP_001280945.1
Coordinates 3623000..3623329 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN312_RS17800 3618157..3619068 + 912 WP_001236044.1 glutathione ABC transporter permease GsiD -
GN312_RS17805 3619246..3621594 + 2349 WP_000950320.1 EAL domain-containing protein -
GN312_RS17810 3621602..3622930 + 1329 WP_000086905.1 GGDEF domain-containing protein -
GN312_RS17815 3623000..3623329 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
GN312_RS17820 3623319..3623705 - 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GN312_RS17825 3623931..3625256 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
GN312_RS17830 3625469..3625852 + 384 WP_000497137.1 biofilm formation regulator BssR -
GN312_RS17835 3625963..3627078 + 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
GN312_RS17840 3627075..3627701 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T144382 WP_000539519.1 NZ_CP046527:c3623705-3623319 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T144382 NZ_CP061941:2390939-2391445 [Marinomonas algicola]
TTGGGAATAAGTGCACCAACACTACTCGCTGATGAGCACCAGATTAACGCCTTTCAATGTGGCATCGAAGAACTCGATAC
TTGGTTAAGAAAGCAGGCGTTAAAAAGTCAAAAACGGGGAACCGCGAGAGTATATGTGGTCAATGACACTGACACCCATC
AAGTGGTCGGGTACTATGCCATTGCCATGGGATCAGTTTCCAGAGAGCAAGCTTTCAGTTCATTAAGAAGAAATAGTCCA
GATCCCATTCCCATGGTGATTCTAGCCAGGCTTGGAGTAGATAACGCCTATCAAGGTCAAGGCATTGCGGCAGGTCTTTT
AAAAGATTGTATCGTTCGCTCAGTACAAGCAATGAACGCTGTCGGTGGAGCAGGAATCTTAGTCCATGCTATTGATGGTA
GTGCGCAAACGTTCTACAAGAAATTTGGCTTCAAAGAATCGACGTTTGATCCTTTAGTACTCATGGCAAGGATCTGCGAT
ATCGAAAAATCATTGTCGATAGACTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT144382 WP_001280945.1 NZ_CP046527:c3623329-3623000 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT144382 NZ_CP061941:2390682-2390948 [Marinomonas algicola]
ATGGCTACAAAGACAGCCCCAATCAACATGCGAGTACTGCCATCGGTAAGAGACATCATCGATGCCGCAGCAAGTTTAAA
AAAAGTTGATAGAACCGTGTTCATTCAGCAAGCAGCGCTCAATGAAGCGCATAGTATACTGGCAGAACAGCGGGATTTTG
TTCTTGAAGCAAAGGCTTTTGAAGCGTTTGATAACGAACTTCGTGCAGAGCCACAGACTCTTGAAGGTATGAAAGATCTG
TTTAAAAGGAAAGCGCCTTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References