Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | zeta-pezA/zeta-couple_hipB |
| Location | 728346..729574 | Replicon | chromosome |
| Accession | NZ_CP046524 | ||
| Organism | Streptococcus oralis strain SOT | ||
Toxin (Protein)
| Gene name | zeta | Uniprot ID | A0A3R9HFX4 |
| Locus tag | GOM47_RS03780 | Protein ID | WP_000405374.1 |
| Coordinates | 728822..729574 (+) | Length | 251 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | - |
| Locus tag | GOM47_RS03775 | Protein ID | WP_000579610.1 |
| Coordinates | 728346..728822 (+) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GOM47_RS03735 (GOM47_03720) | 724603..724887 | + | 285 | WP_000969635.1 | DUF5962 family protein | - |
| GOM47_RS03740 (GOM47_03725) | 724901..725197 | + | 297 | WP_024478354.1 | DUF5966 family protein | - |
| GOM47_RS03745 (GOM47_03730) | 725211..725408 | - | 198 | WP_002876112.1 | hypothetical protein | - |
| GOM47_RS03750 (GOM47_03735) | 725568..726209 | + | 642 | WP_000933087.1 | hypothetical protein | - |
| GOM47_RS03755 (GOM47_03740) | 726219..727304 | + | 1086 | WP_000401910.1 | toprim domain-containing protein | - |
| GOM47_RS03760 (GOM47_03745) | 727355..727588 | + | 234 | WP_000152425.1 | DUF5965 family protein | - |
| GOM47_RS03765 (GOM47_03750) | 727585..727968 | + | 384 | WP_000159224.1 | DUF5945 family protein | - |
| GOM47_RS03770 (GOM47_03755) | 728006..728278 | + | 273 | WP_000494441.1 | hypothetical protein | - |
| GOM47_RS03775 (GOM47_03760) | 728346..728822 | + | 477 | WP_000579610.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| GOM47_RS03780 (GOM47_03765) | 728822..729574 | + | 753 | WP_000405374.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| GOM47_RS03785 (GOM47_03770) | 729623..729901 | + | 279 | WP_000423012.1 | hypothetical protein | - |
| GOM47_RS03790 | 729959..730171 | + | 213 | WP_000521157.1 | hypothetical protein | - |
| GOM47_RS03795 | 730192..730398 | + | 207 | WP_050078263.1 | hypothetical protein | - |
| GOM47_RS03800 (GOM47_03780) | 730595..731491 | - | 897 | WP_050078262.1 | tyrosine-type recombinase/integrase | - |
| GOM47_RS03805 (GOM47_03785) | 731584..732567 | + | 984 | WP_050198294.1 | hypothetical protein | - |
| GOM47_RS03810 (GOM47_03790) | 732564..733277 | - | 714 | WP_050198293.1 | methyltransferase domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | tet(M) / erm(B) | - | 696873..778022 | 81149 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 251 a.a. Molecular weight: 28766.70 Da Isoelectric Point: 7.5812
>T144360 WP_000405374.1 NZ_CP046524:728822-729574 [Streptococcus oralis]
MEIQDYTDSEFKHALARNLRSLTRGRKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGQMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAATVLHDLLFGEWNQVEKEML
KVGEEKLRKF
MEIQDYTDSEFKHALARNLRSLTRGRKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGQMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAATVLHDLLFGEWNQVEKEML
KVGEEKLRKF
Download Length: 753 bp
>T144360 NZ_CP061914:c3814318-3813941 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTTGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACCGAACGGTAAATAACATTACCCTGGGTAAGTATCAGGAGGCGAAACGATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTTGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACCGAACGGTAAATAACATTACCCTGGGTAAGTATCAGGAGGCGAAACGATGA
Antitoxin
Download Length: 159 a.a. Molecular weight: 18217.63 Da Isoelectric Point: 4.3457
>AT144360 WP_000579610.1 NZ_CP046524:728346-728822 [Streptococcus oralis]
MIGKNIKSLRKTHDLTQPEFAQIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
MIGKNIKSLRKTHDLTQPEFAQIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
Download Length: 477 bp
>AT144360 NZ_CP061914:c3814775-3814407 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAATACTTCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTGCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCCCCGGGACAATACTTCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTGCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|