Detailed information of TA system TA144359

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-HTH_XRE
• Location: 1631801..1633044
• Replicon: chromosome
• Accession: NZ_CP046523
• Organism: Streptococcus oralis strain SOD

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: F9P308
• Locus tag: GOM48_RS08200
• Protein ID: WP_000762940.1
• Coordinates: 1631801..1632568 (-)
• Length: 256 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: GOM48_RS08205
• Protein ID: WP_000578854.1
• Coordinates: 1632568..1633044 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GOM48_RS08185 (GOM48_08130)	1627524..1628162	-	639	WP_033585727.1	phosphate uptake regulator PhoU	-
GOM48_RS08190 (GOM48_08135)	1628245..1628976	-	732	WP_000687248.1	protein phosphatase 2C domain-containing protein	-
GOM48_RS08195 (GOM48_08140)	1628963..1631191	-	2229	WP_235097105.1	glycosyl hydrolase family 28-related protein	-
GOM48_RS08200 (GOM48_08145)	1631801..1632568	-	768	WP_000762940.1	type II toxin-antitoxin system toxin PezT	Toxin
GOM48_RS08205 (GOM48_08150)	1632568..1633044	-	477	WP_000578854.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
GOM48_RS08210	1633262..1633495	-	234	WP_235097106.1	hypothetical protein	-
GOM48_RS08215 (GOM48_08160)	1634630..1635640	+	1011	WP_001085615.1	site-specific integrase	-
GOM48_RS08220	1636042..1636785	+	744	WP_235097107.1	hypothetical protein	-
GOM48_RS08225	1636827..1637321	+	495	WP_235097108.1	hypothetical protein	-
GOM48_RS08230 (GOM48_08170)	1637522..1637782	+	261	WP_041784047.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (26-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 256 a.a.
• Molecular weight: 29265.30 Da
• Isoelectric Point: 7.2204

>T144359 WP_000762940.1 NZ_CP046523:c1632568-1631801 [Streptococcus oralis]
MKLEEFSQDNFEQASKRLIRSLTRGKTTSSHPKAILLGGQSGAGKTTIHRIKQREFQGNIIIIDGDSYRSFHPNYLGLQE
KYGKDSVDYTKVFAGQMVEYLVDELSKKGYHLLIEGTLRTTEVPRKTAQLLATRGYQVSLALIATKPELSYLSTLIRYEE
LHAIDPSQARATPKEHHDGIVEHLVDNLRELETAKLFRQIQIYQRDQSCVYNSEVDQISAAEVLHECLFGKWNKVEKEML
KIEQERLRELGEIDK

Nucleotide

• Length: 768 bp

>T144359 NZ_CP061914:3614237-3614455 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18234.87 Da
• Isoelectric Point: 4.7437

>AT144359 WP_000578854.1 NZ_CP046523:c1633044-1632568 [Streptococcus oralis]
MIGENIKTLRKTHKLTQPEFAKIVGISRNSLSRYENGTSRVSTELIDRICKKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
VIKERGANILAQLYRFQDEQGIAFDDTLNPWVLMSDDLSDLINTRIYLVSTFEDIERFNGYLDGIERMLEQATHLVVA

Nucleotide

• Length: 477 bp

>AT144359 NZ_CP061914:3613837-3614211 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: A0A1X1GZB7