144356

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 997261..997873 Replicon chromosome
Accession NZ_CP046521
Organism Streptococcus canis strain HL_100

Toxin (Protein)


Gene name parE Uniprot ID A0A4V0C1F2
Locus tag GE024_RS05070 Protein ID WP_003048651.1
Coordinates 997538..997873 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Q8EDD0
Locus tag GE024_RS05065 Protein ID WP_017648215.1
Coordinates 997261..997548 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GE024_RS05045 992814..994019 + 1206 WP_003048662.1 30S ribosomal protein S1 -
GE024_RS05050 994141..995376 + 1236 WP_093999032.1 D-alanyl-D-alanine carboxypeptidase PBP3 -
GE024_RS05055 995488..996456 - 969 WP_093999033.1 polysaccharide deacetylase family protein -
GE024_RS05060 996642..997084 + 443 Protein_933 hypothetical protein -
GE024_RS05065 997261..997548 + 288 WP_017648215.1 hypothetical protein Antitoxin
GE024_RS05070 997538..997873 + 336 WP_003048651.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GE024_RS05075 998496..999351 + 856 Protein_936 homoserine kinase -
GE024_RS05080 999442..1000710 + 1269 WP_093999035.1 bifunctional folylpolyglutamate synthase/dihydrofolate synthase -
GE024_RS05085 1000742..1001308 + 567 WP_093999036.1 GTP cyclohydrolase I FolE -
GE024_RS05090 1001317..1002117 + 801 WP_093999037.1 dihydropteroate synthase -
GE024_RS05095 1002124..1002483 + 360 WP_093999038.1 dihydroneopterin aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13215.04 Da        Isoelectric Point: 6.2385

>T144356 WP_003048651.1 NZ_CP046521:997538-997873 [Streptococcus canis]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLKVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPARSDYIKLFK

Download         Length: 336 bp

>T144356 NZ_CP061914:2818571-2818678 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10949.53 Da        Isoelectric Point: 4.7271

>AT144356 WP_017648215.1 NZ_CP046521:997261-997548 [Streptococcus canis]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp

>AT144356 NZ_CP061914:c2818524-2818458 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V0C1F2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8EDD0

References