144354

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 126233..126910 Replicon chromosome
Accession NZ_CP046521
Organism Streptococcus canis strain HL_100

Toxin (Protein)


Gene name hicA Uniprot ID V6Z2K9
Locus tag GE024_RS00805 Protein ID WP_015647112.1
Coordinates 126233..126415 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GE024_RS00810 Protein ID WP_093998740.1
Coordinates 126455..126910 (+) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GE024_RS00770 122257..123084 - 828 WP_093999408.1 EbhA -
GE024_RS00775 123510..124169 - 660 WP_093999409.1 helix-turn-helix transcriptional regulator -
GE024_RS00780 124332..124531 + 200 Protein_103 helix-turn-helix transcriptional regulator -
GE024_RS00785 124548..125183 + 636 WP_093999410.1 Bro-N domain-containing protein -
GE024_RS00790 125197..125442 + 246 WP_164403324.1 phage antirepressor protein -
GE024_RS00795 125697..126029 + 333 WP_050319961.1 hypothetical protein -
GE024_RS00805 126233..126415 + 183 WP_015647112.1 type II toxin-antitoxin system HicA family toxin Toxin
GE024_RS00810 126455..126910 + 456 WP_093998740.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GE024_RS00815 127276..128535 - 1260 WP_093998739.1 tyrosine--tRNA ligase -
GE024_RS00820 128642..130942 + 2301 WP_164403322.1 penicillin-binding protein PBP1B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(20-74)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6630.84 Da        Isoelectric Point: 10.8207

>T144354 WP_015647112.1 NZ_CP046521:126233-126415 [Streptococcus canis]
MPMTQKEMVKLLTANGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

>T144354 NZ_CP061914:2511317-2512639 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTCATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGACATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 17065.12 Da        Isoelectric Point: 4.0258

>AT144354 WP_093998740.1 NZ_CP046521:126455-126910 [Streptococcus canis]
MLVTYPALFYYDDTQGETVAPYFVTFPDFEYSATQGEDMADAMAMASEWLGINLADYIENGRDIPKPSDINSLSLVDNNP
FREDKDFRLTYDPNKSFISLVMVDVSEYLGSQEPIKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 456 bp

>AT144354 NZ_CP061914:2511051-2511317 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6Z2K9

Antitoxin

Source ID Structure

References