Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3539929..3540557 Replicon chromosome
Accession NZ_CP046509
Organism Erwinia sp. J780

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag GN242_RS16070 Protein ID WP_154752360.1
Coordinates 3540339..3540557 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag GN242_RS16065 Protein ID WP_154752359.1
Coordinates 3539929..3540309 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN242_RS16035 3534996..3535139 + 144 WP_154752353.1 type B 50S ribosomal protein L36 -
GN242_RS16040 3535475..3536548 + 1074 WP_154752354.1 hypothetical protein -
GN242_RS16045 3536585..3537463 - 879 WP_156287826.1 metal ABC transporter substrate-binding protein -
GN242_RS16050 3537466..3538329 - 864 WP_154752356.1 metal ABC transporter permease -
GN242_RS16055 3538326..3539015 - 690 WP_156287827.1 ATP-binding cassette domain-containing protein -
GN242_RS16060 3539428..3539781 + 354 WP_154752358.1 hypothetical protein -
GN242_RS16065 3539929..3540309 + 381 WP_154752359.1 Hha toxicity modulator TomB Antitoxin
GN242_RS16070 3540339..3540557 + 219 WP_154752360.1 hemolysin expression modulator Hha Toxin
GN242_RS16080 3540848..3541162 + 315 WP_154752361.1 MGMT family protein -
GN242_RS16085 3541190..3541747 - 558 WP_154752362.1 YbaY family lipoprotein -
GN242_RS16090 3541974..3542834 + 861 WP_154752363.1 acyl-CoA thioesterase II -
GN242_RS16095 3542928..3544229 - 1302 WP_154752364.1 ammonium transporter AmtB -
GN242_RS16100 3544249..3544587 - 339 WP_007886947.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8641.09 Da        Isoelectric Point: 8.9007

>T144352 WP_154752360.1 NZ_CP046509:3540339-3540557 [Erwinia sp. J780]
MTDKLLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDDELAIFYSAADHRLAELTMNKLYDKVPVAVWKFVR

Download         Length: 219 bp

>T144352 NZ_CP061914:1946442-1946696 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 14692.39 Da        Isoelectric Point: 4.5911

>AT144352 WP_154752359.1 NZ_CP046509:3539929-3540309 [Erwinia sp. J780]
MDEYSPRRHDIAQLKFLCESLYDESLATLGDSHHGWVNDPTSAVNLQLNDLIEHIAAFTMNYKIKHIEDFDLISQVDEYL
DDTFMLFSNYGINVQDLQRWQKSAKRLFNIFAEECATSRIQASHSF

Download         Length: 381 bp

>AT144352 NZ_CP061914:1946194-1946445 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References