Detailed information of TA system TA144348

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 3275409..3275973
• Replicon: chromosome
• Accession: NZ_CP046507
• Organism: Mycobacterium avium subsp. avium strain DSM 44156

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: X7VBD8
• Locus tag: MAA44156_RS15085
• Protein ID: WP_003875391.1
• Coordinates: 3275409..3275780 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MAA44156_RS15090
• Protein ID: WP_011724021.1
• Coordinates: 3275767..3275973 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MAA44156_RS15045	3270575..3270898	-	324	WP_009975396.1	antibiotic biosynthesis monooxygenase	-
MAA44156_RS15050	3271309..3271833	-	525	WP_033713819.1	glycoside hydrolase	-
MAA44156_RS15055	3271990..3272343	-	354	WP_003875396.1	hypothetical protein	-
MAA44156_RS15060	3272413..3272796	-	384	WP_023884114.1	hypothetical protein	-
MAA44156_RS15065	3272865..3273263	-	399	WP_009975395.1	VOC family protein	-
MAA44156_RS15070	3273365..3273970	-	606	WP_009975394.1	TetR/AcrR family transcriptional regulator; helix-turn-helix transcriptional regulator	-
MAA44156_RS15075	3274066..3274803	+	738	WP_009975393.1	SDR family oxidoreductase	-
MAA44156_RS15080	3274869..3275309	-	441	WP_003875392.1	nitroreductase family deazaflavin-dependent oxidoreductase	-
MAA44156_RS15085	3275409..3275780	-	372	WP_003875391.1	type II toxin-antitoxin system VapC family toxin	Toxin
MAA44156_RS15090	3275767..3275973	-	207	WP_011724021.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
MAA44156_RS15095	3276142..3277086	-	945	WP_003875389.1	HNH endonuclease	-
MAA44156_RS15100	3277286..3278359	-	1074	WP_009975391.1	redox-regulated ATPase YchF	-
MAA44156_RS15105	3278490..3279683	+	1194	WP_080516334.1	hypothetical protein	-
MAA44156_RS15110	3279700..3280698	-	999	WP_009975388.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13770.14 Da
• Isoelectric Point: 6.6003

>T144348 WP_003875391.1 NZ_CP046507:c3275780-3275409 [Mycobacterium avium subsp. avium]
MILVDTSVWIDHLHVADKRLIEFLTNDAIGCHQMVIEELALGAIRRRADLLRLLSNLRAFPLLTHAEVLHLVECHRLWGR
GLSAIDVHLLGSVALVDGARLWTRDKNLKAAGWDVGIAIVDEL

Nucleotide

• Length: 372 bp

>T144348 NZ_CP061914:1001457-1001864 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7261.25 Da
• Isoelectric Point: 11.0634

>AT144348 WP_011724021.1 NZ_CP046507:c3275973-3275767 [Mycobacterium avium subsp. avium]
MRTTVTIDDALLAEAAELTGVTESVALLRQGLQTLVRVESARRLAALGGTDRKASVGPRRRTPADDSR

Nucleotide

• Length: 207 bp

>AT144348 NZ_CP061914:1001210-1001476 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A0E2WB37