Detailed information of TA system TA144347

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 2400463..2401124
• Replicon: chromosome
• Accession: NZ_CP046507
• Organism: Mycobacterium avium subsp. avium strain DSM 44156

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A049E7F1
• Locus tag: MAA44156_RS11225
• Protein ID: WP_023879930.1
• Coordinates: 2400463..2400867 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A049EBE1
• Locus tag: MAA44156_RS11230
• Protein ID: WP_009976405.1
• Coordinates: 2400864..2401124 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MAA44156_RS11200	2395642..2396811	+	1170	WP_009976416.1	acyl-CoA dehydrogenase	-
MAA44156_RS11205	2396800..2397330	-	531	WP_011724637.1	TetR/AcrR family transcriptional regulator	-
MAA44156_RS11210	2397451..2397996	-	546	WP_009976412.1	carboxymuconolactone decarboxylase family protein	-
MAA44156_RS11215	2397993..2398514	-	522	WP_009976411.1	carboxymuconolactone decarboxylase family protein	-
MAA44156_RS11220	2398751..2400316	+	1566	WP_029248458.1	serine/threonine protein kinase	-
MAA44156_RS11225	2400463..2400867	-	405	WP_023879930.1	type II toxin-antitoxin system VapC family toxin	Toxin
MAA44156_RS11230	2400864..2401124	-	261	WP_009976405.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MAA44156_RS11235	2401305..2401757	-	453	WP_029248457.1	VOC family protein	-
MAA44156_RS11240	2401923..2403191	+	1269	WP_023884275.1	cytochrome P450	-
MAA44156_RS11245	2403393..2404853	-	1461	WP_009976402.1	serine/threonine protein kinase	-
MAA44156_RS11250	2405048..2405710	-	663	WP_009976400.1	TetR/AcrR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-124)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-64)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14329.33 Da
• Isoelectric Point: 4.5860

>T144347 WP_023879930.1 NZ_CP046507:c2400867-2400463 [Mycobacterium avium subsp. avium]
MTARPAGVLDTSVFIASESGRHLDEARIPDEVATTVITLAELHAGVLAATTSDVRAQRLATLESIADMEMLPVDDDAARM
WARLRIHLAEAGRRMRANDLWIAGIAASRGLPVVTQDDDFAALDGAANLAIIRV

Nucleotide

• Length: 405 bp

>T144347 NZ_CP061914:c809085-808711 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9495.81 Da
• Isoelectric Point: 11.4633

>AT144347 WP_009976405.1 NZ_CP046507:c2401124-2400864 [Mycobacterium avium subsp. avium]
MSEVASRELRNDTAGVLRRVREGEDVTITVNGRAVAMLTALGPQRRRWLSKAELLSRLRRAQADPGLRQDLATLAGDTTE
DLGPIR

Nucleotide

• Length: 261 bp

>AT144347 NZ_CP061914:c809543-809175 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A049E7F1

Antitoxin

• AlphaFold DB: A0A049EBE1