Detailed information of TA system TA144346

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/ParD(antitoxin)
• Location: 1885418..1886416
• Replicon: chromosome
• Accession: NZ_CP046507
• Organism: Mycobacterium avium subsp. avium strain DSM 44156

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: X7VT18
• Locus tag: MAA44156_RS08765
• Protein ID: WP_003876749.1
• Coordinates: 1885418..1885996 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A049EEK5
• Locus tag: MAA44156_RS08770
• Protein ID: WP_009976725.1
• Coordinates: 1886027..1886416 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MAA44156_RS08740	1881410..1882342	-	933	WP_009976731.1	sigma-70 family RNA polymerase sigma factor	-
MAA44156_RS08745	1882511..1882861	+	351	WP_003878038.1	DoxX family protein	-
MAA44156_RS08750	1882875..1883675	-	801	WP_009976729.1	nuclear transport factor 2 family protein	-
MAA44156_RS08755	1883675..1884235	-	561	WP_155251422.1	pyrazinamidase PncA	-
MAA44156_RS08760	1884346..1885413	+	1068	WP_003876748.1	DoxX family membrane protein	-
MAA44156_RS08765	1885418..1885996	-	579	WP_003876749.1	zeta toxin family protein	Toxin
MAA44156_RS08770	1886027..1886416	-	390	WP_009976725.1	hypothetical protein	Antitoxin
MAA44156_RS08775	1886497..1886991	-	495	WP_009976723.1	gluconokinase	-
MAA44156_RS08780	1886988..1888985	-	1998	WP_009976721.1	phosphotransferase	-
MAA44156_RS08785	1889004..1890521	-	1518	WP_009976720.1	carboxylesterase/lipase family protein	-
MAA44156_RS08790	1890600..1891280	+	681	WP_023861532.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (5-136)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21034.18 Da
• Isoelectric Point: 10.6678

>T144346 WP_003876749.1 NZ_CP046507:c1885996-1885418 [Mycobacterium avium subsp. avium]
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSH
PSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRVRAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRG
PRVVARLSGGLTVGAVDWPAWAPETLRSRWPV

Nucleotide

• Length: 579 bp

>T144346 NZ_CP061914:c611859-611395 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13598.04 Da
• Isoelectric Point: 5.6717

>AT144346 WP_009976725.1 NZ_CP046507:c1886416-1886027 [Mycobacterium avium subsp. avium]
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAELTVEEGVVFNAEI
SAAIDESLARTNYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR

Nucleotide

• Length: 390 bp

>AT144346 NZ_CP061914:c612194-611859 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: A0A0E2W6B4

Antitoxin

• AlphaFold DB: A0A049EEK5