Detailed information of TA system TA144318

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1860015..1860791
• Replicon: chromosome
• Accession: NZ_CP046476
• Organism: Staphylococcus aureus strain MEI001

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: GOL67_RS08910
• Protein ID: WP_000031108.1
• Coordinates: 1860015..1860167 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: GOL67_RS08915
• Protein ID: WP_001251224.1
• Coordinates: 1860192..1860791 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GOL67_RS08895	1856222..1857043	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
GOL67_RS08900	1857495..1858880	-	1386	WP_000116229.1	class II fumarate hydratase	-
GOL67_RS08905	1859076..1859471	-	396	WP_000901023.1	hypothetical protein	-
GOL67_RS08910	1860015..1860167	-	153	WP_000031108.1	hypothetical protein	Toxin
GOL67_RS08915	1860192..1860791	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
GOL67_RS08920	1860950..1861420	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
GOL67_RS08925	1861425..1862552	-	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
GOL67_RS08930	1862704..1863426	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
GOL67_RS08935	1863419..1864876	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T144318 WP_000031108.1 NZ_CP046476:c1860167-1860015 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T144318 NZ_CP061849:1268861-1269043 [Chromobacterium haemolyticum]
GTGACCAGCAAAGAAGTCATCAGCATGATAGAGGCCGACGGCTGGTATCTGGTTGCCGCCAAGGGAAGCCATCAACAGTT
CAAACACCCGATCAAGACCGGCCGGGTGACGGTGCCTCACCCCAAGAAGGACATACCGATAGGCACACTGAACAGCATCA
AGAAACAAGCGGGTCTCAAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT144318 WP_001251224.1 NZ_CP046476:c1860791-1860192 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT144318 NZ_CP061849:1269053-1269463 [Chromobacterium haemolyticum]
ATGTACTACCCGATTGCAGTTGAACCCGGTGATGACCAACATGCCTATGGCGTCATCGTGCCGGATCTACCCGGCTGCTT
TTCCGCCGGGGACACTCTGGATGAGGCCATCCGAAATGCCCGCGAAGCCATTGAGCTACATCTGGAAGGGCTGGTGGAAG
ACCTGGACGTTATCCCTCTGGCCAGCAGTGCGCAGGCTCATGTCGGTAAACCCGAGTTTGCCGGCCATCTCTGGGCGCTG
GTGGATGTGGACATCACTCGCTATCTGGGTAAAGCGACCAAGATCAATGTCACGTTGCCGGCCAACCTTCTGCACCGTAT
CGATGAATATGTCGCTTCCCACCCGGAATATGATAGCCGCAGCGGTTTCCTGGCCAAGACCGCGCTAGAAAAGCTGTTGT
GTCGGCCGTAA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4