Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 822974..823451 Replicon chromosome
Accession NZ_CP046476
Organism Staphylococcus aureus strain MEI001

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag GOL67_RS03865 Protein ID WP_000052076.1
Coordinates 822974..823162 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag GOL67_RS03870 Protein ID WP_001059690.1
Coordinates 823191..823451 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOL67_RS03835 819016..819486 + 471 WP_000824472.1 hypothetical protein -
GOL67_RS03840 819827..820513 + 687 WP_001548082.1 thermonuclease family protein -
GOL67_RS03845 820870..821070 + 201 WP_001059082.1 cold-shock protein -
GOL67_RS03850 821565..821783 - 219 WP_000005884.1 hypothetical protein -
GOL67_RS03855 821845..822129 - 285 WP_001004394.1 hypothetical protein -
GOL67_RS03860 822217..822786 - 570 WP_001106653.1 hypothetical protein -
GOL67_RS03865 822974..823162 - 189 WP_000052076.1 hypothetical protein Toxin
GOL67_RS03870 823191..823451 - 261 WP_001059690.1 hypothetical protein Antitoxin
GOL67_RS03875 823792..823995 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
GOL67_RS03880 823992..824228 - 237 WP_000368687.1 hypothetical protein -
GOL67_RS03885 824453..825034 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
GOL67_RS03890 825107..825724 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
GOL67_RS03895 825879..826373 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
GOL67_RS03900 826772..827194 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
GOL67_RS03905 827342..828058 + 717 WP_000150013.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T144317 WP_000052076.1 NZ_CP046476:c823162-822974 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T144317 NZ_CP061849:1256952-1257206 [Chromobacterium haemolyticum]
ATGCAGATCAAGTTTGATGACAACGCATGGGAGGATTACCTCTACTGGCAGCAGAGCAGCAAGCCTACCCTCAAGCGCAT
CAACGCTCTGATCAAGGACATCCAGCGCAACCCGTTTGAGGGGATCGGCAAGCCTGAGCCGCTTAAGCACCAGTTTGCTG
GCTTCTGGTCGCGTCGCATCGATGAGGAGCATCGGCTGGTCTACGCTGTCCAGAGCAACGTTCTGACCATCTTGCAGTGC
CGCTACCACTACTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT144317 WP_001059690.1 NZ_CP046476:c823451-823191 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT144317 NZ_CP061849:1256689-1256952 [Chromobacterium haemolyticum]
ATGAAAGCGCTTACCTACAGCCATACCCGCCAGCACCTGGCCGAAGTCATGCGTCAAGTGAACGAAGACCGGGCGCCGGT
GATCGTCACCACCCAGCGCGGTGAACCGGTGGTGATCATGTCGCTGGCCGACTACAACGCGCTGGAAGAAACCGCCTACC
TGACGCGCTCCCCTGAAAATGCCAAGCGTCTGGCCGATGCGGCGGCAAGGTTTCACAGCGGGGCGGCCAAAGAGAGAACG
CTTCTCGAAGACGAGGGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References