Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1919686..1920270 Replicon chromosome
Accession NZ_CP046457
Organism Candidatus Syntrophocurvum alkaliphilum isolate B(2M)

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag SYNTR_RS09235 Protein ID WP_156204245.1
Coordinates 1919686..1920030 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag SYNTR_RS09240 Protein ID WP_156204246.1
Coordinates 1920031..1920270 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SYNTR_RS09205 1914693..1916411 - 1719 WP_156204239.1 CotH kinase family protein -
SYNTR_RS09210 1916430..1917095 - 666 WP_197079093.1 leucine-rich repeat domain-containing protein -
SYNTR_RS09215 1917238..1917915 - 678 WP_156204241.1 DUF4956 domain-containing protein -
SYNTR_RS09220 1917912..1918628 - 717 WP_197079094.1 polyphosphate polymerase domain-containing protein -
SYNTR_RS09225 1918871..1919281 - 411 WP_156204243.1 HI0074 family nucleotidyltransferase substrate-binding subunit -
SYNTR_RS09230 1919254..1919592 - 339 WP_156204244.1 nucleotidyltransferase domain-containing protein -
SYNTR_RS09235 1919686..1920030 - 345 WP_156204245.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SYNTR_RS09240 1920031..1920270 - 240 WP_156204246.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SYNTR_RS09245 1920409..1921701 - 1293 WP_156204750.1 ABC transporter permease -
SYNTR_RS09250 1921727..1923385 - 1659 WP_156204247.1 efflux RND transporter periplasmic adaptor subunit -
SYNTR_RS09255 1923382..1924095 - 714 WP_156204248.1 ABC transporter ATP-binding protein -
SYNTR_RS09260 1924268..1924912 - 645 WP_156204249.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-101)

Antitoxin

SpoVT-AbrB domain

(6-50)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12745.71 Da        Isoelectric Point: 4.8550

>T144316 WP_156204245.1 NZ_CP046457:c1920030-1919686 [Candidatus Syntrophocurvum alkaliphilum]
MGYIPEQGDIILIEFDPQTGHEQKGKRPAFVVSNKVFNQFTKLAIVCPITNTNRGFPLHVPLDDRNKTTGVIMCEQGKAL
DIVARNAIFIEKAPDDILEEVVDIYIGFVEITKS

Download         Length: 345 bp

>T144316 NZ_CP061849:1256689-1256952 [Chromobacterium haemolyticum]
ATGAAAGCGCTTACCTACAGCCATACCCGCCAGCACCTGGCCGAAGTCATGCGTCAAGTGAACGAAGACCGGGCGCCGGT
GATCGTCACCACCCAGCGCGGTGAACCGGTGGTGATCATGTCGCTGGCCGACTACAACGCGCTGGAAGAAACCGCCTACC
TGACGCGCTCCCCTGAAAATGCCAAGCGTCTGGCCGATGCGGCGGCAAGGTTTCACAGCGGGGCGGCCAAAGAGAGAACG
CTTCTCGAAGACGAGGGCGAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9134.51 Da        Isoelectric Point: 6.4654

>AT144316 WP_156204246.1 NZ_CP046457:c1920270-1920031 [Candidatus Syntrophocurvum alkaliphilum]
MYTTIQKWGNSQAVRIPKAILEMLEIGENDKVEMKVHDGNLVIIPVKKHKTLKERIAEYEGDYQCGEWDTGKPKGKEEF

Download         Length: 240 bp

>AT144316 NZ_CP061849:1256952-1257206 [Chromobacterium haemolyticum]
ATGCAGATCAAGTTTGATGACAACGCATGGGAGGATTACCTCTACTGGCAGCAGAGCAGCAAGCCTACCCTCAAGCGCAT
CAACGCTCTGATCAAGGACATCCAGCGCAACCCGTTTGAGGGGATCGGCAAGCCTGAGCCGCTTAAGCACCAGTTTGCTG
GCTTCTGGTCGCGTCGCATCGATGAGGAGCATCGGCTGGTCTACGCTGTCCAGAGCAACGTTCTGACCATCTTGCAGTGC
CGCTACCACTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References