Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 152399..153024 Replicon chromosome
Accession NZ_CP046457
Organism Candidatus Syntrophocurvum alkaliphilum isolate B(2M)

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag SYNTR_RS00730 Protein ID WP_156202707.1
Coordinates 152677..153024 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag SYNTR_RS00725 Protein ID WP_156202706.1
Coordinates 152399..152668 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SYNTR_RS00695 147793..148002 - 210 WP_156202700.1 copper ion binding protein -
SYNTR_RS00700 148225..148704 + 480 WP_156202701.1 chemotaxis protein CheW -
SYNTR_RS00705 148783..149154 + 372 WP_156202702.1 holo-ACP synthase -
SYNTR_RS00710 149156..150703 + 1548 WP_156202703.1 NAD(P)H-hydrate dehydratase -
SYNTR_RS00715 150735..151190 + 456 WP_156202704.1 CBS domain-containing protein -
SYNTR_RS00720 151183..152307 + 1125 WP_156202705.1 alanine racemase -
SYNTR_RS00725 152399..152668 + 270 WP_156202706.1 ribbon-helix-helix protein, CopG family Antitoxin
SYNTR_RS00730 152677..153024 + 348 WP_156202707.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SYNTR_RS00735 153088..153771 + 684 WP_197079135.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
SYNTR_RS00740 153857..154993 + 1137 WP_156202709.1 amidohydrolase -
SYNTR_RS00745 154996..155187 + 192 WP_156202710.1 hypothetical protein -
SYNTR_RS00750 155303..156658 + 1356 WP_156202711.1 hypothetical protein -
SYNTR_RS00755 156711..157520 - 810 WP_156202712.1 L,D-transpeptidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12884.19 Da        Isoelectric Point: 9.4654

>T144315 WP_156202707.1 NZ_CP046457:152677-153024 [Candidatus Syntrophocurvum alkaliphilum]
MIKRGEIYFAQLNPVMGSEQGGMRPVLVVQNDIGNQYSPTTIVLAITSQINKAKLPTHVELKSKIYGLEKNSVILAEQIR
TIDKMRLKQRLDILNEDMMEKVDKALAVSMGLAEI

Download         Length: 348 bp

>T144315 NZ_CP061848:c2571694-2571413 [Pseudomonas asiatica]
ATGACCTATAAACTCGAATTCCTGCCTTCGGCACTGAAAGAGTGGGGCAAGCTAGGCCACACCGTGCGCGAACAGATCAA
GAAAAAACTCGCCGAGCGCCTGCAGTCACCCAAGGTACAGGCCGACGCGCTGCGTGACCTGCCGAACCACTACAAAATCA
AGCTCAAGGCCTCTGGATATCGCCTCGTCTATCGAGTCGAGGACGAGCGGATCGTTGTAGTGGTGGTATCGGTTGGCAAA
CGCGAGCGTAGCGAGGTGTATCGATCCGCTCAGAAGCGGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10302.91 Da        Isoelectric Point: 4.6036

>AT144315 WP_156202706.1 NZ_CP046457:152399-152668 [Candidatus Syntrophocurvum alkaliphilum]
MPSSRRIIITVPENLLSEVDNVMADESKNRSEIVREAIKFYLGERKKNLMREQMKKGYLEMAEINLNIATENCCVEEEAL
VNSIEKLLE

Download         Length: 270 bp

>AT144315 NZ_CP061848:c2571929-2571684 [Pseudomonas asiatica]
ATGCAAAACATATTCGCTGACGTGGCCGTAAGCGTGTCGGAACTGAAAAAGAACCCATCCGCGGTGATGACCGGCGCTGC
GGGTATGCCCGTCGCCGTGCTCAATCACAACCGCGTGATGGGTTACATGGTGCCGGCCGAACTGTACGAGGCCATGATGG
AGCGCTTGGAAGATCTCGAATTGAGCGAACTGGCCAAGTCGAGGTTGGGTGAAAAAGGCGTACCGGTTTCCCTGGATGAC
CTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References