Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 3680692..3681328 | Replicon | chromosome |
| Accession | NZ_CP046448 | ||
| Organism | Bacillus subtilis strain ZD01 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G4NU33 |
| Locus tag | GFX43_RS18935 | Protein ID | WP_003156187.1 |
| Coordinates | 3680692..3681042 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | G4NU32 |
| Locus tag | GFX43_RS18940 | Protein ID | WP_003225183.1 |
| Coordinates | 3681047..3681328 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GFX43_RS18895 | 3675735..3676334 | - | 600 | WP_015382836.1 | phosphoserine phosphatase RsbX | - |
| GFX43_RS18900 | 3676334..3677122 | - | 789 | WP_015482833.1 | RNA polymerase sigma factor SigB | - |
| GFX43_RS18905 | 3677088..3677570 | - | 483 | WP_003234299.1 | anti-sigma B factor RsbW | - |
| GFX43_RS18910 | 3677567..3677896 | - | 330 | WP_003234298.1 | anti-sigma factor antagonist RsbV | - |
| GFX43_RS18915 | 3677958..3678965 | - | 1008 | WP_003234295.1 | phosphoserine phosphatase RsbU | - |
| GFX43_RS18920 | 3678977..3679378 | - | 402 | WP_003246640.1 | serine/threonine-protein kinase RsbT | - |
| GFX43_RS18925 | 3679382..3679747 | - | 366 | WP_003225190.1 | RsbT antagonist protein RsbS | - |
| GFX43_RS18930 | 3679752..3680576 | - | 825 | WP_009966610.1 | RsbT co-antagonist protein RsbRA | - |
| GFX43_RS18935 | 3680692..3681042 | - | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| GFX43_RS18940 | 3681047..3681328 | - | 282 | WP_003225183.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
| GFX43_RS18945 | 3681444..3682613 | - | 1170 | WP_015382833.1 | alanine racemase | - |
| GFX43_RS18950 | 3682728..3683744 | - | 1017 | WP_080030712.1 | outer membrane lipoprotein carrier protein LolA | - |
| GFX43_RS18955 | 3683910..3684275 | - | 366 | WP_015252768.1 | holo-ACP synthase | - |
| GFX43_RS18960 | 3684370..3684969 | + | 600 | WP_015482831.1 | rhomboid family intramembrane serine protease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T144314 WP_003156187.1 NZ_CP046448:c3681042-3680692 [Bacillus subtilis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T144314 NZ_CP061848:1361619-1362056 [Pseudomonas asiatica]
GTGATTCTGTGGCGTATCAGCGCCTATGCAGACTTGAGCGGAACGGGCGGCTTGCGTGTCAGCGGCCGCTGGCACCAGGC
GGGCCGGCCAGTGGTATATGCCGCCACCAGCCCGGCCGGGGCAATGCTGGAGGTGCTGGTGCACCTGGAGATCGACCCTG
AGGATTTCCCCACCACCATGCGGCTGCTGCGTATCGAGTTGCCCGACACCGTTTCGCAAGCGCAGTTGCCTGCCTTGCAG
CCTGGCTGGTCGAGCCAGACCGAACTGACCCGGGGCCTGGGCAACCGTTTTCTGGATGAGTGTTCGGCGTTGCTGCTGCC
GGTGCCGAGCGCGATCATGCCCAGCACCACCAATTACCTGTTCAACCCGCGCCATCCGCAGGCAAACAGCGCCAGGCTCG
AGGTCGAGGACTTCACCCCGGACAGCCGGCTGTTTTAG
GTGATTCTGTGGCGTATCAGCGCCTATGCAGACTTGAGCGGAACGGGCGGCTTGCGTGTCAGCGGCCGCTGGCACCAGGC
GGGCCGGCCAGTGGTATATGCCGCCACCAGCCCGGCCGGGGCAATGCTGGAGGTGCTGGTGCACCTGGAGATCGACCCTG
AGGATTTCCCCACCACCATGCGGCTGCTGCGTATCGAGTTGCCCGACACCGTTTCGCAAGCGCAGTTGCCTGCCTTGCAG
CCTGGCTGGTCGAGCCAGACCGAACTGACCCGGGGCCTGGGCAACCGTTTTCTGGATGAGTGTTCGGCGTTGCTGCTGCC
GGTGCCGAGCGCGATCATGCCCAGCACCACCAATTACCTGTTCAACCCGCGCCATCCGCAGGCAAACAGCGCCAGGCTCG
AGGTCGAGGACTTCACCCCGGACAGCCGGCTGTTTTAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10546.92 Da Isoelectric Point: 6.4708
>AT144314 WP_003225183.1 NZ_CP046448:c3681328-3681047 [Bacillus subtilis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT144314 NZ_CP061848:1361173-1361622 [Pseudomonas asiatica]
ATGCTTGCCGAAGTGCTTCGCGACAATGGTTACCACGAGTACCGGGCGCGCCTGCATGCACTGCTGGAAATCCCCGAACT
CGCCAGTGACTTCGAAATCCACACCCGTATCACCCATGGCTTCGCTGCCACCTGGCTGGTGAAACTGACCGAACTCGGCG
TGTTCACCCCTGTGGAGCGTGACCAGATCATTCCCCTGCGCACGCTGAAAACCCGCATCGAACGTGACCAGCCGCTGACC
GTGGAAGAAAGCGACCGGCTGTTCCGCTCGGCCCATATCACCGCCATGGCCGAAGCCGTGTTCGGTGAAGCGGGCAAGGC
AAAACGCTGGCTGTCCAAGCCCAAGGAGCGCTTCTCGGGGCTGACGCCGATGCAGATGCTCACCACCCAGCAGGGCACCA
CCCAGGTCGAGGAGATGTTGCTGCAGATCGCCGAGGGCTTCGGCCTGTGA
ATGCTTGCCGAAGTGCTTCGCGACAATGGTTACCACGAGTACCGGGCGCGCCTGCATGCACTGCTGGAAATCCCCGAACT
CGCCAGTGACTTCGAAATCCACACCCGTATCACCCATGGCTTCGCTGCCACCTGGCTGGTGAAACTGACCGAACTCGGCG
TGTTCACCCCTGTGGAGCGTGACCAGATCATTCCCCTGCGCACGCTGAAAACCCGCATCGAACGTGACCAGCCGCTGACC
GTGGAAGAAAGCGACCGGCTGTTCCGCTCGGCCCATATCACCGCCATGGCCGAAGCCGTGTTCGGTGAAGCGGGCAAGGC
AAAACGCTGGCTGTCCAAGCCCAAGGAGCGCTTCTCGGGGCTGACGCCGATGCAGATGCTCACCACCCAGCAGGGCACCA
CCCAGGTCGAGGAGATGTTGCTGCAGATCGCCGAGGGCTTCGGCCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|