Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | spoIISABC/SpoIISA-SpoIISB |
| Location | 2873839..2874755 | Replicon | chromosome |
| Accession | NZ_CP046448 | ||
| Organism | Bacillus subtilis strain ZD01 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | O34853 |
| Locus tag | GFX43_RS14600 | Protein ID | WP_003244695.1 |
| Coordinates | 2873839..2874585 (+) | Length | 249 a.a. |
Antitoxin (Protein)
| Gene name | spoIISB | Uniprot ID | G4EXD8 |
| Locus tag | GFX43_RS14605 | Protein ID | WP_003232646.1 |
| Coordinates | 2874585..2874755 (+) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GFX43_RS14575 | 2868958..2869065 | - | 108 | WP_144052036.1 | hypothetical protein | - |
| GFX43_RS14580 | 2869167..2870117 | - | 951 | WP_015383451.1 | ring-cleaving dioxygenase | - |
| GFX43_RS14585 | 2870506..2871822 | + | 1317 | WP_015383450.1 | serine/threonine exchanger | - |
| GFX43_RS14590 | 2872098..2872715 | + | 618 | WP_003218470.1 | DUF47 domain-containing protein | - |
| GFX43_RS14595 | 2872728..2873729 | + | 1002 | WP_003232642.1 | inorganic phosphate transporter | - |
| GFX43_RS14600 | 2873839..2874585 | + | 747 | WP_003244695.1 | toxin-antitoxin-antitoxin system toxin SpoIISA | Toxin |
| GFX43_RS14605 | 2874585..2874755 | + | 171 | WP_003232646.1 | three component toxin-antitoxin-antitoxin system antitoxin SpoIISB | Antitoxin |
| GFX43_RS14610 | 2874841..2874978 | + | 138 | WP_003232648.1 | three component toxin-antitoxin-antitoxin system antitoxin SpoIISC | - |
| GFX43_RS14615 | 2875016..2875909 | - | 894 | WP_015483134.1 | N-acetylmuramoyl-L-alanine amidase | - |
| GFX43_RS14620 | 2875922..2876185 | - | 264 | WP_015483133.1 | phage holin | - |
| GFX43_RS14625 | 2876198..2876467 | - | 270 | WP_015252265.1 | hemolysin XhlA family protein | - |
| GFX43_RS14630 | 2876520..2877359 | - | 840 | WP_015383447.1 | phage-like element PBSX protein XepA | - |
| GFX43_RS14635 | 2877406..2877570 | - | 165 | WP_014479563.1 | XkdX family protein | - |
| GFX43_RS14640 | 2877567..2877896 | - | 330 | WP_015483132.1 | XkdW family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2859060..2908773 | 49713 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 249 a.a. Molecular weight: 29061.50 Da Isoelectric Point: 4.6191
>T144313 WP_003244695.1 NZ_CP046448:2873839-2874585 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG
Download Length: 747 bp
>T144313 NZ_CP061848:c1044236-1043661 [Pseudomonas asiatica]
ATGAAGCACTCGCCCTTCACGGCCATTTACGACGCGAACGTTCTTTATCCTGCCCCACTCCGTGATTTCCTGATGAACCT
TGCATTGACAGGTATTTACCGAGCACGTTGGTCAACGAAGATTCATGACGAGTGGAAACGCAATTTATTGCTCAACCGGC
CTGACCTCACCCTCGAGCAAGTAGATCGGACGTCACGGCGAATGGACGCTGCTGTACCTGACGCACTCGTAACTGACTAC
GAGTCGCTGGTAGAAGGGCTGGACTTGCCAGATAAGGATGATCGACATGTCCTCGCTGCTGCAATCAAGTGCAACGCTTC
CGTCATCGTCACCTTCAACCTGAAGGATTTCCCCGAAACGGCTCTCGACGTTTTCGATATCGAGCCCTTACACCCGGATG
ACTTCATCGCCGACCTGTGGGACCTGGACAAGGCAGCAGTACTTGAGGCTGCCCAGCGGCAGCGAATGTCCTTGAAAAAC
CCACCTCACAGCGTGCAGCAGTATCTCGACAGACTGCTTCAGCAAAAGCTTCCCGAGTCGGTGAAGTTGCTTTCAGAATT
CAAATTCCTCCTCTGA
ATGAAGCACTCGCCCTTCACGGCCATTTACGACGCGAACGTTCTTTATCCTGCCCCACTCCGTGATTTCCTGATGAACCT
TGCATTGACAGGTATTTACCGAGCACGTTGGTCAACGAAGATTCATGACGAGTGGAAACGCAATTTATTGCTCAACCGGC
CTGACCTCACCCTCGAGCAAGTAGATCGGACGTCACGGCGAATGGACGCTGCTGTACCTGACGCACTCGTAACTGACTAC
GAGTCGCTGGTAGAAGGGCTGGACTTGCCAGATAAGGATGATCGACATGTCCTCGCTGCTGCAATCAAGTGCAACGCTTC
CGTCATCGTCACCTTCAACCTGAAGGATTTCCCCGAAACGGCTCTCGACGTTTTCGATATCGAGCCCTTACACCCGGATG
ACTTCATCGCCGACCTGTGGGACCTGGACAAGGCAGCAGTACTTGAGGCTGCCCAGCGGCAGCGAATGTCCTTGAAAAAC
CCACCTCACAGCGTGCAGCAGTATCTCGACAGACTGCTTCAGCAAAAGCTTCCCGAGTCGGTGAAGTTGCTTTCAGAATT
CAAATTCCTCCTCTGA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6654.72 Da Isoelectric Point: 11.0203
>AT144313 WP_003232646.1 NZ_CP046448:2874585-2874755 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
Download Length: 171 bp
>AT144313 NZ_CP061848:c1044700-1044233 [Pseudomonas asiatica]
ATGACCACCGCCGACCTCTCTCGCAAGATGCTTCCCGATGAGAAAGAGATTGCCGTGGCAGTCGAATCGAGCCGAACGCT
AGCAGCCTTCCTCTCGACAAAATCAGATACCCAACGGATTGAGCTGCTCAATGAAGAGAATCAGCGCCAGGTTGTTGAAG
TACCTACCTTCGCGCTGCGTCTGTTTGGCGAGATTCTCAGCGAGCTGGCTCTGGGGAACTCGGTCAAAGTCGTTCCAATC
CACGCCGAATTGACTACCCAAGAGGCAGCAGACCTACTCAACGTCTCTCGGCCGTACTTGGTAAAACTGCTAGACGAATC
TGTGATTCCTCACACAAAAACGGGTCGCCATCGTCGGGTCAAATTCTCCGACCTGGTTGCCTACAAGGACAAACGTGACG
AGGTAAGCCGTGCCGCAATGGACGCGCTGGCAGCCGAAGCCCAGGAGTTACGGATGGGGTACGAATGA
ATGACCACCGCCGACCTCTCTCGCAAGATGCTTCCCGATGAGAAAGAGATTGCCGTGGCAGTCGAATCGAGCCGAACGCT
AGCAGCCTTCCTCTCGACAAAATCAGATACCCAACGGATTGAGCTGCTCAATGAAGAGAATCAGCGCCAGGTTGTTGAAG
TACCTACCTTCGCGCTGCGTCTGTTTGGCGAGATTCTCAGCGAGCTGGCTCTGGGGAACTCGGTCAAAGTCGTTCCAATC
CACGCCGAATTGACTACCCAAGAGGCAGCAGACCTACTCAACGTCTCTCGGCCGTACTTGGTAAAACTGCTAGACGAATC
TGTGATTCCTCACACAAAAACGGGTCGCCATCGTCGGGTCAAATTCTCCGACCTGGTTGCCTACAAGGACAAACGTGACG
AGGTAAGCCGTGCCGCAATGGACGCGCTGGCAGCCGAAGCCCAGGAGTTACGGATGGGGTACGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|