Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4630166..4630782 Replicon chromosome
Accession NZ_CP046446
Organism Leclercia sp. J807

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GNG26_RS22055 Protein ID WP_103825282.1
Coordinates 4630166..4630537 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GNG26_RS22060 Protein ID WP_023618112.1
Coordinates 4630540..4630782 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNG26_RS22040 4627666..4628568 + 903 WP_103825279.1 formate dehydrogenase subunit beta -
GNG26_RS22045 4628565..4629200 + 636 WP_103825280.1 formate dehydrogenase cytochrome b556 subunit -
GNG26_RS22050 4629197..4630126 + 930 WP_103825281.1 formate dehydrogenase accessory protein FdhE -
GNG26_RS22055 4630166..4630537 - 372 WP_103825282.1 type II toxin-antitoxin system VapC family toxin Toxin
GNG26_RS22060 4630540..4630782 - 243 WP_023618112.1 ribbon-helix-helix protein, CopG family Antitoxin
GNG26_RS22065 4630905..4631846 - 942 WP_032615389.1 fatty acid biosynthesis protein FabY -
GNG26_RS22070 4631891..4632328 - 438 WP_103177564.1 D-tyrosyl-tRNA(Tyr) deacylase -
GNG26_RS22075 4632325..4633206 - 882 WP_114316354.1 virulence factor BrkB family protein -
GNG26_RS22080 4633200..4633799 - 600 WP_103825284.1 glucose-1-phosphatase -
GNG26_RS22085 4633919..4634719 - 801 WP_103825285.1 DeoR/GlpR family DNA-binding transcription regulator -
GNG26_RS22090 4634754..4635650 - 897 WP_156240093.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13608.75 Da        Isoelectric Point: 6.9792

>T144312 WP_103825282.1 NZ_CP046446:c4630537-4630166 [Leclercia sp. J807]
VEHMAVFDTNILIDLFNNRVEAADTIDRTAAHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDITREIAERSVLLR
EKHGMKLPDAIILATAQSRNCPLISRNTKDFAGIAGVVSPYQL

Download         Length: 372 bp

>T144312 NZ_CP061847:726813-727133 [Lysobacter sp. CW239]
ATGGCTGAAATAGTCTGGACGGAACCGGCTCTGAGCGACTTGGACGCCATTGCCGACTACATTGCCATTGAGAACCCCCT
GGCAGCGGCAGAGCTGGTCCGCCGCGTTATCGGCCACGTGGAACAATTGGCCGATCACCCTGAGAGTGGTAGTCGCCCCA
TAGAGCTCAAGCGTTCACGCTACCGACAAATCGTCGAACCGCCATGCCGTATCTTCTGCCGCCATGACGGGCGTAAAGTT
TTTATCCTGCATCTCATGCGTTCGGAGCGTGTGCTCCGCAAGACGCGGCTGGCCTCCCGTGCCAAGAAGTCAAAGGGGTG
A

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9427.72 Da        Isoelectric Point: 4.3224

>AT144312 WP_023618112.1 NZ_CP046446:c4630782-4630540 [Leclercia sp. J807]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLKNQPRAELLREAIELYLDQQSSSIIRDALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp

>AT144312 NZ_CP061847:726568-726825 [Lysobacter sp. CW239]
ATGCGTACTGAACTCGTCACCACCCTTAAGCGCCAGGCAACCGAACTCCTCTCGGACATCGAGCGGGACAAAACGCCTAT
TCTCATCACCCAGCATGGCCTGCCCAGTGCCTACCTCGTAGATGTGGAGAGCTATGAGCTCCTGCAGCAACGCATGACCG
TTCTGGAGGGTATTGCCCGCGGTGAGCTCGCCGTTGCCGAAGGTCGCGTTGTCTCGCATGCCCAAGCCAAGACCCGCCTT
ACCCGATGGCTGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References