Detailed information of TA system TA144311

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 4346053..4346639
• Replicon: chromosome
• Accession: NZ_CP046446
• Organism: Leclercia sp. J807

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: GNG26_RS20655
• Protein ID: WP_103824771.1
• Coordinates: 4346053..4346421 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: GNG26_RS20660
• Protein ID: WP_156239917.1
• Coordinates: 4346418..4346639 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GNG26_RS20635	4341683..4342753	-	1071	WP_156239911.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-
GNG26_RS20640	4342755..4343600	-	846	WP_114316496.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
GNG26_RS20645	4343597..4344484	-	888	WP_156239913.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
GNG26_RS20650	4344587..4345903	-	1317	WP_156239915.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
GNG26_RS20655	4346053..4346421	-	369	WP_103824771.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
GNG26_RS20660	4346418..4346639	-	222	WP_156239917.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GNG26_RS20665	4346787..4347500	-	714	WP_103177352.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
GNG26_RS20670	4347502..4348269	-	768	WP_039032512.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
GNG26_RS20675	4348266..4349543	-	1278	WP_156239919.1	high-affinity branched-chain amino acid ABC transporter permease LivM	-
GNG26_RS20680	4349540..4350466	-	927	WP_013099131.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
GNG26_RS20685	4350514..4351623	-	1110	WP_156239921.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4338130..4348269	10139

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (6-122)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-53)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13632.91 Da
• Isoelectric Point: 8.5625

>T144311 WP_103824771.1 NZ_CP046446:c4346421-4346053 [Leclercia sp. J807]
MNLQFISAEEIVLFHDKLLSVTPGVAGMSDPGRAEALLHRVLNKYQYEGVTDVWILAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLKANPDYVAMTVEAAAGRLSLEEIVERLRR

Nucleotide

• Length: 369 bp

>T144311 NZ_CP061847:470143-470424 [Lysobacter sp. CW239]
ATGTCCATTCAGTCCTTCCAGTGCGCCGAGACCGAAAGTTTTTTCAACGGAAGAACGGTCAAAAAATTTGAGGGTTTTAA
AAAGGTTGCAATGCGAAAACTCGCCATGCTCGACGCCGCCAAGGCGTTGAATGATCTGCGAGTTCCGCCAGCCAATCGGC
TGGAGCCTCTCCGGGGTGACCGGGAGGGCCAGCACAGCATCCGGGTCAATGACCAGTTTCGTGTGTGTTTCATCTGGGCC
GATGCCGGCCCTACCAACGTCGAAATCTGCGACTACCACTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8078.10 Da
• Isoelectric Point: 5.6579

>AT144311 WP_156239917.1 NZ_CP046446:c4346639-4346418 [Leclercia sp. J807]
MRTMNYSEARQNLASALDSAATGTPVTITRRGHKPAVIISVEEFERYQAAKLDAEFDAIMGIHGNEIRELADK

Nucleotide

• Length: 222 bp

>AT144311 NZ_CP061847:470434-470730 [Lysobacter sp. CW239]
ATGCGTTCTGTTCCCTATCCCCATCCGGGCGAAATTCTGCTTGAAGAGTTCCTGGTTCCTCTTGGAATCAGCCAATACAA
GCTCGCCAAGGCCATTGATGTGCCGCAGACGCGCATCAGCGCGATCATCGCCGGCCGTCGCAGCATCACGGCGGATACGG
CCCTGCGCCTGGCCAGGTTCTTCAGCATGTCCGATAGCTTCTGGATGAACCTGCAGGTCGGTCACGACGCTGCGCAGGCC
AGGGATGAACTGGCCGATGTGCTGGCCCATATCGAGCCCTACGAGCACGCAGCCTGA