Detailed information of TA system TA144301

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipB(antitoxin)
• Location: 2291911..2292395
• Replicon: chromosome
• Accession: NZ_CP046446
• Organism: Leclercia sp. J807

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GNG26_RS11105
• Protein ID: WP_147271012.1
• Coordinates: 2291911..2292051 (-)
• Length: 47 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: GNG26_RS11110
• Protein ID: WP_156238708.1
• Coordinates: 2292144..2292395 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GNG26_RS11090	2287415..2288596	-	1182	WP_156238705.1	PLP-dependent aminotransferase family protein	-
GNG26_RS11095	2288730..2290724	-	1995	WP_156238706.1	TonB-dependent receptor	-
GNG26_RS11100	2290735..2291805	-	1071	WP_156238707.1	YncE family protein	-
GNG26_RS11105	2291911..2292051	-	141	WP_147271012.1	type II toxin-antitoxin system HipA family toxin	Toxin
GNG26_RS11110	2292144..2292395	-	252	WP_156238708.1	helix-turn-helix domain-containing protein	Antitoxin
GNG26_RS11115	2293157..2296948	+	3792	WP_156238709.1	glycosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 47 a.a.
• Molecular weight: 5111.78 Da
• Isoelectric Point: 4.5148

>T144301 WP_147271012.1 NZ_CP046446:c2292051-2291911 [Leclercia sp. J807]
MKEMADRTDEVIATVRAELPTDFPEQISGAIFRGLASQAARISRFD

Nucleotide

• Length: 141 bp

>T144301 NZ_CP061842:c4429278-4428745 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCCAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGTATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9294.64 Da
• Isoelectric Point: 9.8449

>AT144301 WP_156238708.1 NZ_CP046446:c2292395-2292144 [Leclercia sp. J807]
MKVTTAGALAQAVRDQRKVNKLTQSETAEQVGIKQTTVSDFENKPESTKLETLFKILAALDLELHVVKRGSTLPDNPSWK
KEW

Nucleotide

• Length: 252 bp

>AT144301 NZ_CP061842:c4429555-4429289 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA