Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipB(antitoxin)
Location 2291911..2292395 Replicon chromosome
Accession NZ_CP046446
Organism Leclercia sp. J807

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GNG26_RS11105 Protein ID WP_147271012.1
Coordinates 2291911..2292051 (-) Length 47 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GNG26_RS11110 Protein ID WP_156238708.1
Coordinates 2292144..2292395 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNG26_RS11090 2287415..2288596 - 1182 WP_156238705.1 PLP-dependent aminotransferase family protein -
GNG26_RS11095 2288730..2290724 - 1995 WP_156238706.1 TonB-dependent receptor -
GNG26_RS11100 2290735..2291805 - 1071 WP_156238707.1 YncE family protein -
GNG26_RS11105 2291911..2292051 - 141 WP_147271012.1 type II toxin-antitoxin system HipA family toxin Toxin
GNG26_RS11110 2292144..2292395 - 252 WP_156238708.1 helix-turn-helix domain-containing protein Antitoxin
GNG26_RS11115 2293157..2296948 + 3792 WP_156238709.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 47 a.a.        Molecular weight: 5111.78 Da        Isoelectric Point: 4.5148

>T144301 WP_147271012.1 NZ_CP046446:c2292051-2291911 [Leclercia sp. J807]
MKEMADRTDEVIATVRAELPTDFPEQISGAIFRGLASQAARISRFD

Download         Length: 141 bp

>T144301 NZ_CP061842:c4429278-4428745 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCCAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGTATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9294.64 Da        Isoelectric Point: 9.8449

>AT144301 WP_156238708.1 NZ_CP046446:c2292395-2292144 [Leclercia sp. J807]
MKVTTAGALAQAVRDQRKVNKLTQSETAEQVGIKQTTVSDFENKPESTKLETLFKILAALDLELHVVKRGSTLPDNPSWK
KEW

Download         Length: 252 bp

>AT144301 NZ_CP061842:c4429555-4429289 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References