Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1056460..1057079 Replicon chromosome
Accession NZ_CP046446
Organism Leclercia sp. J807

Toxin (Protein)


Gene name Hha Uniprot ID A0A345CDT0
Locus tag GNG26_RS04900 Protein ID WP_032616864.1
Coordinates 1056460..1056678 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag GNG26_RS04905 Protein ID WP_103824066.1
Coordinates 1056687..1057079 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNG26_RS04880 1053329..1053682 + 354 WP_156237938.1 DUF1428 family protein -
GNG26_RS04885 1053715..1055283 - 1569 WP_156237939.1 EAL domain-containing protein -
GNG26_RS04890 1055541..1055681 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
GNG26_RS04895 1055732..1056196 - 465 WP_156237940.1 hypothetical protein -
GNG26_RS04900 1056460..1056678 - 219 WP_032616864.1 hemolysin expression modulator Hha Toxin
GNG26_RS04905 1056687..1057079 - 393 WP_103824066.1 Hha toxicity modulator TomB Antitoxin
GNG26_RS04910 1057567..1060707 - 3141 WP_103178504.1 multidrug efflux RND transporter permease subunit AcrB -
GNG26_RS04915 1060730..1061923 - 1194 WP_103824067.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1046205..1057079 10874


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T144298 WP_032616864.1 NZ_CP046446:c1056678-1056460 [Leclercia sp. J807]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Download         Length: 219 bp

>T144298 NZ_CP061842:1810410-1810512 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15164.08 Da        Isoelectric Point: 4.8941

>AT144298 WP_103824066.1 NZ_CP046446:c1057079-1056687 [Leclercia sp. J807]
MDEYSPKRQDIAQLKFLCESLYHDCLTNLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNASRANPLVSPVKIITNN

Download         Length: 393 bp

>AT144298 NZ_CP061842:c1810519-1810374 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A345CDT0

Antitoxin

Source ID Structure

References