Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) KacT-ataR/DUF1778(antitoxin)
Location 550780..551574 Replicon chromosome
Accession NZ_CP046446
Organism Leclercia sp. J807

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag GNG26_RS02565 Protein ID WP_156237690.1
Coordinates 550780..551301 (-) Length 174 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag GNG26_RS02570 Protein ID WP_103823103.1
Coordinates 551305..551574 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNG26_RS02540 546060..546221 + 162 WP_156237687.1 DUF1127 domain-containing protein -
GNG26_RS02545 546316..547707 - 1392 WP_156237688.1 PLP-dependent aminotransferase family protein -
GNG26_RS02550 547808..548287 + 480 WP_114316000.1 carboxymuconolactone decarboxylase family protein -
GNG26_RS02555 548274..549176 - 903 WP_103823097.1 LysR family transcriptional regulator -
GNG26_RS02560 549277..550692 + 1416 WP_156237689.1 aldehyde dehydrogenase family protein -
GNG26_RS02565 550780..551301 - 522 WP_156237690.1 GNAT family N-acetyltransferase Toxin
GNG26_RS02570 551305..551574 - 270 WP_103823103.1 DUF1778 domain-containing protein Antitoxin
GNG26_RS02575 551899..552288 + 390 WP_114315996.1 hypothetical protein -
GNG26_RS02580 552385..552852 + 468 WP_156237691.1 MarR family transcriptional regulator -
GNG26_RS02585 552852..553919 + 1068 WP_103823106.1 HlyD family secretion protein -
GNG26_RS02590 553922..555001 + 1080 WP_103823107.1 DUF2955 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(83-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19467.39 Da        Isoelectric Point: 8.9092

>T144296 WP_156237690.1 NZ_CP046446:c551301-550780 [Leclercia sp. J807]
VTKLTIRMFSHEARYDLTDFNCGDSTLNRFLFDHLARQHSGRLLRAYLLVTDDPEPKVLGYYTLSGSCFEKETLPSKTQQ
HKVPYVNVPSVTLGRLAIHQDFQGQGWGMTLVTHAMKVVYLASQAVGIHGMFVDALNDKAKAFYLKLGFISLTGSNANSL
FYPTKSIEKLFVE

Download         Length: 522 bp

>T144296 NZ_CP061842:350384-350710 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10334.68 Da        Isoelectric Point: 4.8839

>AT144296 WP_103823103.1 NZ_CP046446:c551574-551305 [Leclercia sp. J807]
MSALKKQRIDLRLTEEDKDLIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLILNENSWNRVMDALDNPPEPNDQLKR
AAKRLQNME

Download         Length: 270 bp

>AT144296 NZ_CP061842:350731-351030 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACATAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References