Detailed information of TA system TA144295

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 463332..463848
• Replicon: chromosome
• Accession: NZ_CP046446
• Organism: Leclercia sp. J807

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GNG26_RS02180
• Protein ID: WP_103178030.1
• Coordinates: 463564..463848 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GNG26_RS02175
• Protein ID: WP_103178029.1
• Coordinates: 463332..463574 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GNG26_RS02160	459393..460133	+	741	WP_156237631.1	KDGP aldolase family protein	-
GNG26_RS02165	460188..461324	+	1137	WP_156237633.1	lactonase family protein	-
GNG26_RS02170	461344..463254	+	1911	WP_156237635.1	BglG family transcription antiterminator	-
GNG26_RS02175	463332..463574	+	243	WP_103178029.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GNG26_RS02180	463564..463848	+	285	WP_103178030.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GNG26_RS02185	463852..464316	-	465	WP_103823049.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
GNG26_RS02190	464422..466560	-	2139	WP_156237637.1	anaerobic ribonucleoside-triphosphate reductase	-
GNG26_RS02195	466931..468586	-	1656	WP_156237639.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-65)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10898.68 Da
• Isoelectric Point: 10.4610

>T144295 WP_103178030.1 NZ_CP046446:463564-463848 [Leclercia sp. J807]
MTYELEFDPRALKEWQKLGDTVKSQFKKKLAVVLSNPRRESARLHGLPDCYKIKLSSSGYRLVYQVRDKVITVFVVAVGK
REKSAVYHDANQRL

Nucleotide

• Length: 285 bp

>T144295 NZ_CP061842:324414-324782 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTTATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9057.44 Da
• Isoelectric Point: 5.1088

>AT144295 WP_103178029.1 NZ_CP046446:463332-463574 [Leclercia sp. J807]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTVTVSDSEDELIRTVRERLANPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT144295 NZ_CP061842:324196-324417 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA