144294

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 49099..49760 Replicon chromosome
Accession NZ_CP046446
Organism Leclercia sp. J807

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GNG26_RS00245 Protein ID WP_156237424.1
Coordinates 49362..49760 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GNG26_RS00240 Protein ID WP_156237423.1
Coordinates 49099..49365 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNG26_RS00210 44119..44433 - 315 WP_103824276.1 PTS sugar transporter subunit IIB -
GNG26_RS00215 44728..45675 + 948 WP_156237420.1 LacI family transcriptional regulator -
GNG26_RS00220 45712..46008 - 297 WP_156237421.1 hypothetical protein -
GNG26_RS00225 46329..46748 + 420 WP_103824278.1 GNAT family N-acetyltransferase -
GNG26_RS00230 46745..47404 - 660 WP_103824279.1 TetR/AcrR family transcriptional regulator -
GNG26_RS00235 47482..48981 + 1500 WP_156237422.1 MFS transporter -
GNG26_RS00240 49099..49365 + 267 WP_156237423.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GNG26_RS00245 49362..49760 + 399 WP_156237424.1 type II toxin-antitoxin system VapC family toxin Toxin
GNG26_RS00250 50021..50527 - 507 WP_156237425.1 hypothetical protein -
GNG26_RS00255 50852..51655 + 804 WP_103824283.1 lipoprotein NlpA -
GNG26_RS00260 51783..52562 + 780 WP_156237426.1 MBL fold metallo-hydrolase -
GNG26_RS00265 52588..53550 + 963 WP_156237427.1 helix-turn-helix domain-containing protein -
GNG26_RS00270 53570..54658 - 1089 WP_156237428.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14652.79 Da        Isoelectric Point: 6.6410

>T144294 WP_156237424.1 NZ_CP046446:49362-49760 [Leclercia sp. J807]
MKHMLDTNIVSHLFKRHPGVVNRMANLKPADVCISSITEAELLYGADKKQSTRLKETIKTFLSTITIYDWDSDAAAAYGK
LRAEMETRGKVMADLDQLIAAHAISRGTTIVTNDHAFGMVQELTIEDWTTAA

Download         Length: 399 bp

>T144294 NZ_CP061841:49626-49913 [Legionella pneumophila subsp. pneumophila]
ATGATCTATGAGTTACATTTCCATCCGCTTGCGTTAAAAGAATGGAAGAAACTATCGAAGGAGTTGCAGGAACAGTTTAA
AAAACTATTAAAACGGCGACTGGAAAATCCGCATGTTATTTCTGCCAAACTTAGTGGCCATCTTAAAGATTGCTATAAGA
TAAAATTGCATCAGGCCGGCTATAGATTGGTCTACCAAGTTAACGATAATAAAATGATTCTCCTTGTTGTTGCTGTAGGC
AAGCGAAACAAAAATAAAGTCTATGAGTCAGCAGAAGATAGGACTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10037.44 Da        Isoelectric Point: 4.8896

>AT144294 WP_156237423.1 NZ_CP046446:49099-49365 [Leclercia sp. J807]
MERKAKLFKKGLNQAVLLPAEFAFDAESVLIRRDEEGNVVLAAKPAKEKSWDEFFRMLENTTVPDSFLSPEERNQSITKR
DPLDGVQV

Download         Length: 267 bp

>AT144294 NZ_CP061841:49385-49636 [Legionella pneumophila subsp. pneumophila]
ATGCAAACTTTATATGCAACACAAGTCGCTAGCATTAGCGAATTAAAGAAAAATCCCACAAAACTTATTAATGATGCTCA
TGGGATGCCCGTGGTGATTCTTAACCATAATGTAGCTGCTGCTTATTTAATTCCAGCAGAAACTTTTGAAAAACTGATGG
ATGCTGTTGACGAAAGCGAGCTAAAAAGCATTGTAGAACAACGCCTTTCAGAGCCCTTTACGCCAGTTAAGGTTGCGCTT
GATGATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References