Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4540032..4540618 Replicon chromosome
Accession NZ_CP046445
Organism Leclercia sp. 119287

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag GNG27_RS21850 Protein ID WP_142487420.1
Coordinates 4540032..4540400 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag GNG27_RS21855 Protein ID WP_142487421.1
Coordinates 4540397..4540618 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNG27_RS21830 4535661..4536731 - 1071 WP_142487416.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
GNG27_RS21835 4536733..4537578 - 846 WP_142487417.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
GNG27_RS21840 4537575..4538462 - 888 WP_156264801.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
GNG27_RS21845 4538563..4539879 - 1317 WP_156264802.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
GNG27_RS21850 4540032..4540400 - 369 WP_142487420.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
GNG27_RS21855 4540397..4540618 - 222 WP_142487421.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GNG27_RS21860 4540766..4541479 - 714 WP_156264803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
GNG27_RS21865 4541481..4542248 - 768 WP_142487422.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
GNG27_RS21870 4542245..4543522 - 1278 WP_156264804.1 high-affinity branched-chain amino acid ABC transporter permease LivM -
GNG27_RS21875 4543519..4544445 - 927 WP_039032510.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
GNG27_RS21880 4544497..4545606 - 1110 WP_156264805.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4534924..4543522 8598


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(29-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13645.94 Da        Isoelectric Point: 8.4948

>T144292 WP_142487420.1 NZ_CP046445:c4540400-4540032 [Leclercia sp. 119287]
MTLQFISAEEIVLFHDKLLSVTPGVAGMSDPGRAEALLYRVLNKYQYEGVTDVWILAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLKANPDYVAMTVEAAAGRLSLEEIVERLRR

Download         Length: 369 bp

>T144292 NZ_CP061840:c68132-66834 [Legionella pneumophila subsp. pneumophila]
ATGCGTAAATTATACATATTGATGAACAATGAGCTCGTGGGGGTGCTTACCCAGGATAATGCAGGTGGTTTGAGTTTTTC
CTACGTTGCTGACTGGATTTCCAAGCCGCATTCACGCCCAGTTTCTTTATCGTTACCGTTAATAAATCAAAGGTTTTCAG
GAGAAGTTGTTTATAACTTTTTTGATAATTTACTTCCCGATAATCCACAGATAAGAGCGAGAATTCAAGCTCGTTTTCAG
GCAAAATCATCGCGACCGTTTGATTTATTGGCGTTAATTGGCGGTGATTGTGTTGGTGCAATACAAATTGTTGAACGTAT
TCCTCAGACACAGCGTCTAAGCATTGAAAGTCACGTTGTCAGTGAGGCCGAGATAGCTCGTACTTTACGTTCTTACCAAA
CCTCACCACTGGGAATGGATAAAGAGGATGATGAGTTTAGAATCTCAATAGCCGGTGCTCAGGAAAAAACGGCTTTTCTA
TATTACCAAAATGAATGGCATAAACCATTTGGACCTACACCAACAACTCACATATTCAAATTACCTATTGGATATTTACC
ACATCAAGGAATTGATTTAAGTGAGAGTTGTGAAAATGAGCATCTCTGTTTACTACTAGCCAGCAAATTTGGTTTAGAGG
TTGCAAAATCAAAAATCTTACAATTCGAAGATGAAAAGGTGCTGGTTGTCGAAAGATTTGATAGAAAATGGAGTCGAGAT
AACCGTTATATACTCAGGTTACCGCAAGAAGACCTATGCCAAGCGTTGGGTTATTCACCAAATTTAAAATATCAGTCAGA
TGGTGGCCCCGGTATTAAAGAAATTATGCAGCTACTTAATGGCTCACAGCAGCCTCAAAAAGATAGAGATGAATTTTTCA
GAGCACAGGTTGTTTACTGGTGCCTTGGTGCTATTGATGCGCATGCCAAAAACTTCAGTATAAGTATACAACCACAAGGC
GGTTACCAGCTCACCCCCTTATACGACATCATTTCAGCCTATGCTATCGTGGAACAAAAACAGCTATCCTTTAAGAAATT
GAAAATGGCAATGGCTTTATATGGTAAAAATAGTCATTACAAGATTGACGGTATTCAAAAAAGACACTTTATTGAAACAG
CAAAATACGTTCAATATTCTAAAATTAAAGCAGCTCAGATTTTTGAACAAGTGATTGACCGTATTGATTCTGCTATCGAT
GAGGTCTCAACACAATTACCAAACCACTTCCCAGAAAAGATTGCAGATCCAATCTTCAAAGGGATGAGAGCTTTTAAGGA
GCGAATGATATCCACATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8078.10 Da        Isoelectric Point: 5.6579

>AT144292 WP_142487421.1 NZ_CP046445:c4540618-4540397 [Leclercia sp. 119287]
MRTMNYSEARQNLASALDSAATGTPVTITRRGHKPAVIISAEEFERYQVAKLDAEFDAIMGIHGNEIRELADK

Download         Length: 222 bp

>AT144292 NZ_CP061840:c68371-68132 [Legionella pneumophila subsp. pneumophila]
ATGATCATTAGCTCAGCAAAAGATTTAGCATTATATTTAAATGACAAGCGCAAACAACTCAAAATGAGTCAATCTGAAGT
TGCCGATTTAGTCGGCTTAAAACAGGATACCATATCAAAGTTTGAAAATAGCCCTGATAATAGTCGAATTGATACCTTAT
TTAGAATATTGTCCGCCCTAAATTTAAATATGAGCCTTGTTGAAAAAGATCAAAAAACTCATGAAGATATAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References