Detailed information of TA system TA144292

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 4540032..4540618
• Replicon: chromosome
• Accession: NZ_CP046445
• Organism: Leclercia sp. 119287

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: GNG27_RS21850
• Protein ID: WP_142487420.1
• Coordinates: 4540032..4540400 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: GNG27_RS21855
• Protein ID: WP_142487421.1
• Coordinates: 4540397..4540618 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GNG27_RS21830	4535661..4536731	-	1071	WP_142487416.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-
GNG27_RS21835	4536733..4537578	-	846	WP_142487417.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
GNG27_RS21840	4537575..4538462	-	888	WP_156264801.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
GNG27_RS21845	4538563..4539879	-	1317	WP_156264802.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
GNG27_RS21850	4540032..4540400	-	369	WP_142487420.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
GNG27_RS21855	4540397..4540618	-	222	WP_142487421.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GNG27_RS21860	4540766..4541479	-	714	WP_156264803.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
GNG27_RS21865	4541481..4542248	-	768	WP_142487422.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
GNG27_RS21870	4542245..4543522	-	1278	WP_156264804.1	high-affinity branched-chain amino acid ABC transporter permease LivM	-
GNG27_RS21875	4543519..4544445	-	927	WP_039032510.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
GNG27_RS21880	4544497..4545606	-	1110	WP_156264805.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4534924..4543522	8598

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (29-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-50)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13645.94 Da
• Isoelectric Point: 8.4948

>T144292 WP_142487420.1 NZ_CP046445:c4540400-4540032 [Leclercia sp. 119287]
MTLQFISAEEIVLFHDKLLSVTPGVAGMSDPGRAEALLYRVLNKYQYEGVTDVWILAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLKANPDYVAMTVEAAAGRLSLEEIVERLRR

Nucleotide

• Length: 369 bp

>T144292 NZ_CP061840:c68132-66834 [Legionella pneumophila subsp. pneumophila]
ATGCGTAAATTATACATATTGATGAACAATGAGCTCGTGGGGGTGCTTACCCAGGATAATGCAGGTGGTTTGAGTTTTTC
CTACGTTGCTGACTGGATTTCCAAGCCGCATTCACGCCCAGTTTCTTTATCGTTACCGTTAATAAATCAAAGGTTTTCAG
GAGAAGTTGTTTATAACTTTTTTGATAATTTACTTCCCGATAATCCACAGATAAGAGCGAGAATTCAAGCTCGTTTTCAG
GCAAAATCATCGCGACCGTTTGATTTATTGGCGTTAATTGGCGGTGATTGTGTTGGTGCAATACAAATTGTTGAACGTAT
TCCTCAGACACAGCGTCTAAGCATTGAAAGTCACGTTGTCAGTGAGGCCGAGATAGCTCGTACTTTACGTTCTTACCAAA
CCTCACCACTGGGAATGGATAAAGAGGATGATGAGTTTAGAATCTCAATAGCCGGTGCTCAGGAAAAAACGGCTTTTCTA
TATTACCAAAATGAATGGCATAAACCATTTGGACCTACACCAACAACTCACATATTCAAATTACCTATTGGATATTTACC
ACATCAAGGAATTGATTTAAGTGAGAGTTGTGAAAATGAGCATCTCTGTTTACTACTAGCCAGCAAATTTGGTTTAGAGG
TTGCAAAATCAAAAATCTTACAATTCGAAGATGAAAAGGTGCTGGTTGTCGAAAGATTTGATAGAAAATGGAGTCGAGAT
AACCGTTATATACTCAGGTTACCGCAAGAAGACCTATGCCAAGCGTTGGGTTATTCACCAAATTTAAAATATCAGTCAGA
TGGTGGCCCCGGTATTAAAGAAATTATGCAGCTACTTAATGGCTCACAGCAGCCTCAAAAAGATAGAGATGAATTTTTCA
GAGCACAGGTTGTTTACTGGTGCCTTGGTGCTATTGATGCGCATGCCAAAAACTTCAGTATAAGTATACAACCACAAGGC
GGTTACCAGCTCACCCCCTTATACGACATCATTTCAGCCTATGCTATCGTGGAACAAAAACAGCTATCCTTTAAGAAATT
GAAAATGGCAATGGCTTTATATGGTAAAAATAGTCATTACAAGATTGACGGTATTCAAAAAAGACACTTTATTGAAACAG
CAAAATACGTTCAATATTCTAAAATTAAAGCAGCTCAGATTTTTGAACAAGTGATTGACCGTATTGATTCTGCTATCGAT
GAGGTCTCAACACAATTACCAAACCACTTCCCAGAAAAGATTGCAGATCCAATCTTCAAAGGGATGAGAGCTTTTAAGGA
GCGAATGATATCCACATAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8078.10 Da
• Isoelectric Point: 5.6579

>AT144292 WP_142487421.1 NZ_CP046445:c4540618-4540397 [Leclercia sp. 119287]
MRTMNYSEARQNLASALDSAATGTPVTITRRGHKPAVIISAEEFERYQVAKLDAEFDAIMGIHGNEIRELADK

Nucleotide

• Length: 222 bp

>AT144292 NZ_CP061840:c68371-68132 [Legionella pneumophila subsp. pneumophila]
ATGATCATTAGCTCAGCAAAAGATTTAGCATTATATTTAAATGACAAGCGCAAACAACTCAAAATGAGTCAATCTGAAGT
TGCCGATTTAGTCGGCTTAAAACAGGATACCATATCAAAGTTTGAAAATAGCCCTGATAATAGTCGAATTGATACCTTAT
TTAGAATATTGTCCGCCCTAAATTTAAATATGAGCCTTGTTGAAAAAGATCAAAAAACTCATGAAGATATAGAATGGTAA