Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4002773..4003433 Replicon chromosome
Accession NZ_CP046445
Organism Leclercia sp. 119287

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag GNG27_RS19170 Protein ID WP_156264582.1
Coordinates 4002773..4003186 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag GNG27_RS19175 Protein ID WP_142487010.1
Coordinates 4003167..4003433 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNG27_RS19150 3998776..4000509 - 1734 WP_156264580.1 single-stranded-DNA-specific exonuclease RecJ -
GNG27_RS19155 4000515..4001228 - 714 WP_156264581.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GNG27_RS19160 4001250..4002146 - 897 WP_142487007.1 site-specific tyrosine recombinase XerD -
GNG27_RS19165 4002248..4002769 + 522 WP_142487008.1 flavodoxin FldB -
GNG27_RS19170 4002773..4003186 - 414 WP_156264582.1 protein YgfX Toxin
GNG27_RS19175 4003167..4003433 - 267 WP_142487010.1 FAD assembly factor SdhE Antitoxin
GNG27_RS19180 4003739..4004719 + 981 WP_142487011.1 tRNA-modifying protein YgfZ -
GNG27_RS19185 4004814..4005473 - 660 WP_142487012.1 hemolysin III family protein -
GNG27_RS19190 4005639..4005950 - 312 WP_156264583.1 N(4)-acetylcytidine aminohydrolase -
GNG27_RS19195 4006002..4006733 + 732 WP_142490021.1 MurR/RpiR family transcriptional regulator -
GNG27_RS19200 4006847..4008280 + 1434 WP_156264584.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16213.00 Da        Isoelectric Point: 10.6531

>T144290 WP_156264582.1 NZ_CP046445:c4003186-4002773 [Leclercia sp. 119287]
VVLWQSDLRVSWRAQWMSLLLHGLVAACILLMPWPLSYTPLWLILLSLVVFDSVRSQRRINSRQGEIKLFMDSRLHWQGS
EWEIVGTPWMLNAGMMLRLRKGDGKRYHHLWLAADSMDEGEWRDLRRMLSQQPTQGR

Download         Length: 414 bp

>T144290 NZ_CP061839:1524881-1525141 [Treponema pedis]
ATGTGGATAATAAAATATGCAAAGGAAGCTGTAAGGGACAGTAAAAAAATCGAGCGGTCAAACTTAAAACAAACTGTTAT
AAATTTAATTGAAATATTAAAAATAAATCCTTTCCAAAATCCTCCGCCTTATGAAAAATTACTAGGAGATTTGACCGGAA
AATATTCCAGAAGAATAAATATTCAACATCGTTTAGTTTATGAAGTTTTTGAAAATAAAAATACTGTTCGTATTCTTAGA
ATGTGGACACATTATGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10539.02 Da        Isoelectric Point: 4.5242

>AT144290 WP_142487010.1 NZ_CP046445:c4003433-4003167 [Leclercia sp. 119287]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKQLFIRLLENDDPDLFNWLMNHGEPADAELQRMVLLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT144290 NZ_CP061839:1524639-1524881 [Treponema pedis]
ATGATGGTAATGACGACAACACAAGCTCGCAGTAATTTACATACGTTAATTGATAAGACAAAAAATTTTCATGAACCGAT
TATTATTTCAGGAAAACGGCATAATGCCGTACTAATTTCGGAAGAAGACTGGAATTCAATTCAGGAAACTCTGTATTTAT
ATTCCGTTCCCGGACTTAGAGAATCTATTATAGAGGCAAGTAAAGAACCTTTGGAAAACAGTATTGAGGATATCGGCTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References