Detailed information of TA system TA144279

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2376371..2377945
• Replicon: chromosome
• Accession: NZ_CP046445
• Organism: Leclercia sp. 119287

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GNG27_RS11520
• Protein ID: WP_156263758.1
• Coordinates: 2376371..2377690 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: GNG27_RS11525
• Protein ID: WP_142489448.1
• Coordinates: 2377694..2377945 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GNG27_RS11505	2371896..2373077	-	1182	WP_156263756.1	PLP-dependent aminotransferase family protein	-
GNG27_RS11510	2373177..2375171	-	1995	WP_142489445.1	TonB-dependent receptor	-
GNG27_RS11515	2375182..2376243	-	1062	WP_156263757.1	YncE family protein	-
GNG27_RS11520	2376371..2377690	-	1320	WP_156263758.1	type II toxin-antitoxin system HipA family toxin	Toxin
GNG27_RS11525	2377694..2377945	-	252	WP_142489448.1	helix-turn-helix domain-containing protein	Antitoxin
GNG27_RS11530	2378752..2382552	+	3801	WP_156263759.1	glycosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 48588.03 Da
• Isoelectric Point: 6.9657

>T144279 WP_156263758.1 NZ_CP046445:c2377690-2376371 [Leclercia sp. 119287]
MRAKRLTVAMNGDVIGTLHRDGSGAMSFQYAPAWLAEPGSRAISLSLPLQHGRISGAPVFNFFSNLLPDSEAIIARMQAR
FQVETTHPFDLLASVGRDCVGAIQLYPPGQEIPPVTDIVAEPLDDDQIAALLEGYQMAPLGMTEEGADFRISLAGAQEKT
ALLWYQDRWQRPQGSTPTSHIFKLPIGRIEQNNIDLSESCENEWLCLRIAKAFGFPVAHADMAQFGRKKVLIIERFDRRW
ARSGWLMRLPQEDFCQALGVSPALKYESHGGPGIADAMKLLLGSRLAGQDREMFFKAQILFWMLAAIDGHGKNFSLFIEA
DSSFRMAPLYDVISAFPLFDAGGIPLKKAKMAMALQGKNRQYHFAMILPRHFISTAAFAGFSQEAARRLMTEMAAVTDDV
IATVRAELPTDFPLPVSEAIFRGLARQAARIGRFNELTP

Nucleotide

• Length: 1320 bp

>T144279 NZ_CP061832:328376-328744 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9166.46 Da
• Isoelectric Point: 9.8953

>AT144279 WP_142489448.1 NZ_CP046445:c2377945-2377694 [Leclercia sp. 119287]
MKVTSADALAQAVRDQRKVNKLTQTATAEQVGIKQTTVSDFENKPGSTKLDTLFKILAALDLELHVVKRGATLPDNNAWT
KEW

Nucleotide

• Length: 252 bp

>AT144279 NZ_CP061832:328158-328379 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA