Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 564291..564832 Replicon chromosome
Accession NZ_CP046445
Organism Leclercia sp. 119287

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag GNG27_RS02715 Protein ID WP_156262797.1
Coordinates 564524..564832 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag GNG27_RS02710 Protein ID WP_156262796.1
Coordinates 564291..564524 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNG27_RS02670 559964..560695 + 732 WP_156262793.1 topoisomerase II -
GNG27_RS02680 561085..561192 + 108 Protein_519 integrase -
GNG27_RS02685 561247..561944 + 698 Protein_520 IS1 family transposase -
GNG27_RS02690 561954..562915 + 962 Protein_521 IS3 family transposase -
GNG27_RS02695 563021..563359 + 339 WP_156262794.1 helix-turn-helix domain-containing protein -
GNG27_RS02700 563368..563541 + 174 WP_156262795.1 hypothetical protein -
GNG27_RS02705 563851..564149 + 299 Protein_524 DUF1176 domain-containing protein -
GNG27_RS02710 564291..564524 + 234 WP_156262796.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
GNG27_RS02715 564524..564832 + 309 WP_156262797.1 CcdB family protein Toxin
GNG27_RS02720 565011..565694 - 684 WP_156262798.1 DNA-binding transcriptional regulator CsiR -
GNG27_RS02725 565740..567023 - 1284 WP_156262799.1 4-aminobutyrate--2-oxoglutarate transaminase -
GNG27_RS02730 567041..568489 - 1449 WP_156262800.1 NADP-dependent succinate-semialdehyde dehydrogenase -
GNG27_RS02735 568513..569781 - 1269 WP_156262801.1 L-2-hydroxyglutarate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(7-77)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11399.01 Da        Isoelectric Point: 4.6712

>T144273 WP_156262797.1 NZ_CP046445:564524-564832 [Leclercia sp. 119287]
MQYCVYRNRAGGNYPLLLDVQSNIIGDLDRRMVVPLTEADNFGGMTLPKRLIFTLYINGTEYTAVTVDMASVPNSGLGEK
VADVAHYRQTIKDSIDFLFDGF

Download         Length: 309 bp

>T144273 NZ_CP061817:490652-490993 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8882.99 Da        Isoelectric Point: 6.3370

>AT144273 WP_156262796.1 NZ_CP046445:564291-564524 [Leclercia sp. 119287]
MTRTALKRAVTLTVDPALYDEVKQSGANMSAILNNALLEEQKRLQGERWKEENREGIQALNRFLEENGSFSDQVRRF

Download         Length: 234 bp

>AT144273 NZ_CP061817:490422-490652 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References