Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-MazE |
Location | 48567..49229 | Replicon | chromosome |
Accession | NZ_CP046445 | ||
Organism | Leclercia sp. 119287 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | GNG27_RS00250 | Protein ID | WP_197090550.1 |
Coordinates | 48831..49229 (+) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | GNG27_RS00245 | Protein ID | WP_156265014.1 |
Coordinates | 48567..48827 (+) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GNG27_RS00210 | 43584..43898 | - | 315 | WP_032615638.1 | PTS sugar transporter subunit IIB | - |
GNG27_RS00215 | 44193..45140 | + | 948 | WP_142487693.1 | LacI family transcriptional regulator | - |
GNG27_RS00220 | 45178..45474 | - | 297 | WP_032615642.1 | hypothetical protein | - |
GNG27_RS00225 | 45504..45767 | + | 264 | WP_142487694.1 | hypothetical protein | - |
GNG27_RS00230 | 45796..46215 | + | 420 | WP_142487695.1 | GNAT family N-acetyltransferase | - |
GNG27_RS00235 | 46212..46871 | - | 660 | WP_156262610.1 | TetR/AcrR family transcriptional regulator | - |
GNG27_RS00240 | 46950..48449 | + | 1500 | WP_156262611.1 | MFS transporter | - |
GNG27_RS00245 | 48567..48827 | + | 261 | WP_156265014.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
GNG27_RS00250 | 48831..49229 | + | 399 | WP_197090550.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
GNG27_RS00255 | 49488..49994 | - | 507 | WP_142487698.1 | hypothetical protein | - |
GNG27_RS00260 | 50334..51137 | + | 804 | WP_142487699.1 | lipoprotein NlpA | - |
GNG27_RS00270 | 51356..51604 | - | 249 | WP_156262612.1 | ribbon-helix-helix domain-containing protein | - |
GNG27_RS00275 | 51785..52564 | + | 780 | WP_156262613.1 | MBL fold metallo-hydrolase | - |
GNG27_RS00280 | 52591..53544 | + | 954 | WP_156262614.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 14730.88 Da Isoelectric Point: 5.9000
>T144272 WP_197090550.1 NZ_CP046445:48831-49229 [Leclercia sp. 119287]
MLHMLDTNIVSHLVKQHPSVVDRYSQIAPEEMCISSITEAELLYGVAKKQSHRLHETISEFLKTITVCDWDSDAAAIYGK
LRASMEKRGKVMGDLDQLIAAHALSRGTTIVTNDRAFAMVQELTIEDWTTAA
MLHMLDTNIVSHLVKQHPSVVDRYSQIAPEEMCISSITEAELLYGVAKKQSHRLHETISEFLKTITVCDWDSDAAAIYGK
LRASMEKRGKVMGDLDQLIAAHALSRGTTIVTNDRAFAMVQELTIEDWTTAA
Download Length: 399 bp
>T144272 NZ_CP061817:194240-194506 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 10236.62 Da Isoelectric Point: 9.8080
>AT144272 WP_156265014.1 NZ_CP046445:48567-48827 [Leclercia sp. 119287]
MERKAKLFKKGRNQAVLLPAEFAFDTENVWLRRDEEGNVVLRAMSEKERHRENFLRLLKQTQVPDSFLSKEERNQSYTTR
DPLEGL
MERKAKLFKKGRNQAVLLPAEFAFDTENVWLRRDEEGNVVLRAMSEKERHRENFLRLLKQTQVPDSFLSKEERNQSYTTR
DPLEGL
Download Length: 261 bp
>AT144272 NZ_CP061817:193977-194240 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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