144272

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 48567..49229 Replicon chromosome
Accession NZ_CP046445
Organism Leclercia sp. 119287

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GNG27_RS00250 Protein ID WP_197090550.1
Coordinates 48831..49229 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GNG27_RS00245 Protein ID WP_156265014.1
Coordinates 48567..48827 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNG27_RS00210 43584..43898 - 315 WP_032615638.1 PTS sugar transporter subunit IIB -
GNG27_RS00215 44193..45140 + 948 WP_142487693.1 LacI family transcriptional regulator -
GNG27_RS00220 45178..45474 - 297 WP_032615642.1 hypothetical protein -
GNG27_RS00225 45504..45767 + 264 WP_142487694.1 hypothetical protein -
GNG27_RS00230 45796..46215 + 420 WP_142487695.1 GNAT family N-acetyltransferase -
GNG27_RS00235 46212..46871 - 660 WP_156262610.1 TetR/AcrR family transcriptional regulator -
GNG27_RS00240 46950..48449 + 1500 WP_156262611.1 MFS transporter -
GNG27_RS00245 48567..48827 + 261 WP_156265014.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GNG27_RS00250 48831..49229 + 399 WP_197090550.1 type II toxin-antitoxin system VapC family toxin Toxin
GNG27_RS00255 49488..49994 - 507 WP_142487698.1 hypothetical protein -
GNG27_RS00260 50334..51137 + 804 WP_142487699.1 lipoprotein NlpA -
GNG27_RS00270 51356..51604 - 249 WP_156262612.1 ribbon-helix-helix domain-containing protein -
GNG27_RS00275 51785..52564 + 780 WP_156262613.1 MBL fold metallo-hydrolase -
GNG27_RS00280 52591..53544 + 954 WP_156262614.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14730.88 Da        Isoelectric Point: 5.9000

>T144272 WP_197090550.1 NZ_CP046445:48831-49229 [Leclercia sp. 119287]
MLHMLDTNIVSHLVKQHPSVVDRYSQIAPEEMCISSITEAELLYGVAKKQSHRLHETISEFLKTITVCDWDSDAAAIYGK
LRASMEKRGKVMGDLDQLIAAHALSRGTTIVTNDRAFAMVQELTIEDWTTAA

Download         Length: 399 bp

>T144272 NZ_CP061817:194240-194506 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10236.62 Da        Isoelectric Point: 9.8080

>AT144272 WP_156265014.1 NZ_CP046445:48567-48827 [Leclercia sp. 119287]
MERKAKLFKKGRNQAVLLPAEFAFDTENVWLRRDEEGNVVLRAMSEKERHRENFLRLLKQTQVPDSFLSKEERNQSYTTR
DPLEGL

Download         Length: 261 bp

>AT144272 NZ_CP061817:193977-194240 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References