Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1669974..1670605 Replicon chromosome
Accession NZ_CP046444
Organism Granulicella sp. 5B5

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GOB94_RS07035 Protein ID WP_182278125.1
Coordinates 1669974..1670162 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GOB94_RS07040 Protein ID WP_182278126.1
Coordinates 1670183..1670605 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOB94_RS07005 1666241..1666411 - 171 WP_182278120.1 hypothetical protein -
GOB94_RS07010 1666542..1667291 - 750 WP_182278121.1 glucose 1-dehydrogenase -
GOB94_RS07015 1667484..1667909 + 426 WP_182278122.1 metalloregulator ArsR/SmtB family transcription factor -
GOB94_RS07020 1668343..1668906 + 564 WP_182278489.1 SRPBCC domain-containing protein -
GOB94_RS07025 1668903..1669373 + 471 WP_182278123.1 SRPBCC domain-containing protein -
GOB94_RS07030 1669433..1669849 + 417 WP_182278124.1 VOC family protein -
GOB94_RS07035 1669974..1670162 + 189 WP_182278125.1 type II toxin-antitoxin system HicA family toxin Toxin
GOB94_RS07040 1670183..1670605 + 423 WP_182278126.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GOB94_RS07045 1670626..1673094 - 2469 WP_182278127.1 glucan 1,4-alpha-glucosidase -
GOB94_RS07050 1673381..1673992 + 612 WP_182278128.1 superoxide dismutase -
GOB94_RS07055 1674063..1674290 - 228 WP_182278129.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-122)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6994.19 Da        Isoelectric Point: 11.1572

>T144268 WP_182278125.1 NZ_CP046444:1669974-1670162 [Granulicella sp. 5B5]
MSSRELIQALIRDGWFEVAHAGSHKQFKHATKPGRVTVPYPKRDLPLGTLKSIEKQAGLKLR

Download         Length: 189 bp

>T144268 NZ_CP061801:c3987064-3986687 [Enterobacter mori]
ATGCAAACACAACCTGTTCCCCCGACACAGGAGGCTTCACCACGCCCGTCACCAGTGGAGATCTGGCTCCGCCTTTTGAG
TCACCTGCTGGACCGTCACTACGGTCTGACGTTAAACGACACGCCATTTTGCAATGATGGTGTGATCCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATACGCCCTGATACGCACCGATCGTCACGGTTTC
AGCGCAGAAACACAGTCCCCACTCATCAGCAGTATTGATATCCTTCGCGCCCGTAAGGCCTGTGGACTGATGGCACGCAA
TGGCTACAGACTGGTGACCGATATCACCACCGGCAAATACAGCGAGGTGACTCGATGA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15458.67 Da        Isoelectric Point: 8.9222

>AT144268 WP_182278126.1 NZ_CP046444:1670183-1670605 [Granulicella sp. 5B5]
MEYIAYLHKDKGSDYGVSFPDFPGCVTAGKSLEEARRMAVEALTLHMAGMLEDGEAIPEPSTLDQLAKDPAMRGAVAFLV
SAEPPEKTVRINITARESQIETIDRLARARGMTRSAYMVQSAVRITTTRERTRGTARRRA

Download         Length: 423 bp

>AT144268 NZ_CP061801:c3987440-3987114 [Enterobacter mori]
ATCGCCGAACCCTGGTGGGGGCTTAAACGCGATATCACACCCTGTTTTGGCGCTCGCCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTCGCCGACCGCGCCAGTATCACCGGGCAGTTCAGCGACGCGGATTTACGCCATCTGGACCAGGCATTTCCGC
TGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCAATCCCCGCCATCAGCACGGCGTCACGCTCTACGCA
AAAGGGCTGACCTGCAACGCGGATACACTCGGCAGTTGCGGATATGTCTATATAGCGATTTACCCGACACCTGCAACAAC
AGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References