Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 843720..844300 Replicon chromosome
Accession NZ_CP046444
Organism Granulicella sp. 5B5

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag GOB94_RS03665 Protein ID WP_182277553.1
Coordinates 843720..844013 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag GOB94_RS03670 Protein ID WP_182277554.1
Coordinates 844010..844300 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOB94_RS03635 839093..840115 - 1023 WP_182278412.1 sugar kinase -
GOB94_RS03640 840227..841063 - 837 WP_182277549.1 5-dehydro-4-deoxy-D-glucuronate isomerase -
GOB94_RS03645 841125..841526 - 402 WP_182277550.1 cupin domain-containing protein -
GOB94_RS03650 841676..842182 + 507 WP_182277551.1 twin-arginine translocation signal domain-containing protein -
GOB94_RS03655 842193..842969 + 777 WP_182277552.1 glucose 1-dehydrogenase -
GOB94_RS03660 843181..843627 + 447 WP_182278413.1 hypothetical protein -
GOB94_RS03665 843720..844013 + 294 WP_182277553.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GOB94_RS03670 844010..844300 + 291 WP_182277554.1 putative addiction module antidote protein Antitoxin
GOB94_RS03675 844352..845470 - 1119 WP_182277555.1 acyltransferase -
GOB94_RS03680 845582..846601 - 1020 WP_182278414.1 rod shape-determining protein -
GOB94_RS03685 846761..848539 - 1779 WP_182277556.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-92)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10732.44 Da        Isoelectric Point: 10.2588

>T144265 WP_182277553.1 NZ_CP046444:843720-844013 [Granulicella sp. 5B5]
VIEIRETETFAGWLSQLRDDRAKAKIAVRVRRLAFGNPGDIKPVGEGVSELRIPHGPGYRVYFIQRGSLLIVLLCGGDKS
SQNKDIATAKKLAKEEL

Download         Length: 294 bp

>T144265 NZ_CP061801:3539191-3539514 [Enterobacter mori]
ATTTCATCTGTACCGGCCACGGTGCCGGTTTCGTCACGCCTGTCGCCCGTGCAGGTCTGGCAGCAACTGTTGACGTATCT
GCTGGAGCAGCACTACGGCCTGACTCTCAACGACACACCATTTCATGACGACACGGCCATTGAGGAGCATATCGATGCGG
GAATAACGCTTGCCGATGCTGTTAATTTCCTGGTCGAAAAGTACGAACTGGTTCGTATCGATCGGAAGGGATTTTCATGG
CAAGAACAAACCCCGTATATTTCCGTAGTAGATATTTTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAATGTGAA
ATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 9913.21 Da        Isoelectric Point: 4.5338

>AT144265 WP_182277554.1 NZ_CP046444:844010-844300 [Granulicella sp. 5B5]
MTAAKTKPFDPAAYLDSPEAIATYLTEALETGDPAFVADALGVVARARGMSEVAHAAGVSRESLYRALSAEGNPEFGTVL
KVAQALGVRLAFETAA

Download         Length: 291 bp

>AT144265 NZ_CP061801:3538830-3539153 [Enterobacter mori]
ATGCAAAATTCATGGGGACTGAAGCGCGACATCTCGCCGTGCTTCGGTGCAAGACTTGTGCAGGAAGGCTGTCGCCTGCA
TTTTCTGGCGGACCGTGCGGGTATTAGCGGTACGTTTAACAAGGACGAGGCGCTGCGTCTGGATCAGGCGTTTCCGCTAG
TGATGAAACAGCTTGAATTGATGCTGACAACCGGTGAACTGAATCTGCGCCATCAGCATTGCGTCACGTTGCATCATAAC
GGACTCACCTGCGAGGCTGATACTCTGGGCTCTCACGGCTATGTTTACATCGTTATTTATCCGCAGGCATCTGCAACCCA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References