Detailed information of TA system TA144261

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 32293..32840
• Replicon: plasmid pR19.2839_83k
• Accession: NZ_CP046430
• Organism: Salmonella enterica strain R19.2839

Toxin (Protein)

• Gene name: parE
• Uniprot ID: E9LLH3
• Locus tag: GJS36_RS23795
• Protein ID: WP_000969996.1
• Coordinates: 32293..32574 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1M1SX19
• Locus tag: GJS36_RS23800
• Protein ID: WP_021546940.1
• Coordinates: 32571..32840 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJS36_RS23775	28109..28798	+	690	WP_001764183.1	hypothetical protein	-
GJS36_RS23780	29142..29846	+	705	WP_001067852.1	IS6-like element IS26 family transposase	-
GJS36_RS23785	29901..31451	+	1551	Protein_32	Tn3-like element TnAs1 family transposase	-
GJS36_RS23790	31752..31961	-	210	Protein_33	transposase	-
GJS36_RS23795	32293..32574	-	282	WP_000969996.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GJS36_RS23800	32571..32840	-	270	WP_021546940.1	hypothetical protein	Antitoxin
GJS36_RS23805	33587..34198	+	612	Protein_36	IS3 family transposase	-
GJS36_RS23810	34230..34409	-	180	WP_012600012.1	hypothetical protein	-
GJS36_RS23815	34633..34950	+	318	WP_032156934.1	hypothetical protein	-
GJS36_RS23820	35058..35945	+	888	WP_021546939.1	WYL domain-containing protein	-
GJS36_RS23825	35955..36554	+	600	WP_001021938.1	DUF1819 family protein	-
GJS36_RS23830	36551..37135	+	585	WP_000645940.1	DUF1788 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..83365	83365

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (95-144)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 13852.62 Da
• Isoelectric Point: 5.5500

>T144261 WP_000969996.1 NZ_CP046430:c32574-32293 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Nucleotide

• Length: 282 bp

>T144261 NZ_CP061801:c1604635-1604162 [Enterobacter mori]
ATGATTTTTTATCGTCTGGTGACGGGACGTTATGCCAGCGAAGCGTGGAGTGGAAGCGGTGCAAACCAGTATGGTGGCCG
CTGGAATCATAAAGGACACCCTGCGGTGTACGTCTCCACATCCATCTCGCTGGCAGCGCTCGAAATTCTGGTTCACGTTA
AAAGGGATACCGTACTGAATCAATACCAACTGTTCAGCATCGATATCCCGGACGATCAGATTGATCATCTGGATAAAGAG
TGGCTGCCCGGGGACTGGCAGGAAAATCCAGCTCCGGTTTCAACGATGGACCTGGGAACCAGCTGGCTACAGGCCAGTGA
TGCACTGGCACTTATTTTACCTTCCTGCATTATTCCTTATGAAAACAATGCCATTCTCAACCCATTGAACCCGGCATTTC
AACAGGCTTTATCCTCCGTTCAGCGCCACTCTTTTGTATTCGATACCCGGCTGGCAGAAAAAACCGCACCCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 13263.91 Da
• Isoelectric Point: 5.5500

>AT144261 WP_021546940.1 NZ_CP046430:c32840-32571 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFF

Nucleotide

• Length: 270 bp

>AT144261 NZ_CP061801:c1605075-1604632 [Enterobacter mori]
ATGAGAACATGGGTTCCCGCGCAGAAACCTGCTGACAACGCACTTTGGCGTTTTGCAGGTTTGCCTGCAAACAGAGGTAT
GCGGCTGATTGAATATCTCAATCAGGGCTTGCCCGTCAGCGTACTTGACAACATTCATGAATGGACCGCGATGTCAAAAG
CGGACATTTTACGCGTGACAGGGATTAACGAGCGCAATGTCGCGCGCCGCAAAAGTGCGGGCCGTACGCTGACGCCCGAT
GAAAGCGAACGCGTGGCTCGTTTCGTTCGGGTACTGGATACCGCTGTCGATTATTTTGGCAGTAAAGACGAGGCATGGAA
CTGGCTGCAATCACCGGTTCGCGGGCTTGGCAATATAGCACCTGTCGACCTGATTGCCACAGAAACCGGCGCACTGGAAG
TCACCGACCTGATTGGCCGTCTGGAACACGGAGTGCTGGCATGA

Structures

Toxin

• AlphaFold DB: E9LLH3

Antitoxin

• AlphaFold DB: A0A1M1SX19