Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 11953..12545 | Replicon | plasmid pS4-mcr1.1 |
Accession | NZ_CP046418 | ||
Organism | Escherichia coli strain LZYWN_4 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | V0AGQ2 |
Locus tag | GJV83_RS23645 | Protein ID | WP_000520549.1 |
Coordinates | 11953..12201 (+) | Length | 83 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | V0AWG0 |
Locus tag | GJV83_RS23650 | Protein ID | WP_000681613.1 |
Coordinates | 12198..12545 (+) | Length | 116 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GJV83_RS23615 | 8830..9345 | + | 516 | WP_001025395.1 | J domain-containing protein | - |
GJV83_RS23620 | 9450..9992 | + | 543 | WP_001083906.1 | hypothetical protein | - |
GJV83_RS23625 | 9989..10240 | + | 252 | WP_001230707.1 | hypothetical protein | - |
GJV83_RS23630 | 10227..10454 | + | 228 | WP_000801440.1 | hypothetical protein | - |
GJV83_RS23635 | 10908..11207 | + | 300 | WP_000650309.1 | hypothetical protein | - |
GJV83_RS23640 | 11298..11648 | + | 351 | WP_000854259.1 | hypothetical protein | - |
GJV83_RS23645 | 11953..12201 | + | 249 | WP_000520549.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
GJV83_RS23650 | 12198..12545 | + | 348 | WP_000681613.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
GJV83_RS23655 | 12906..13409 | + | 504 | WP_000781813.1 | hypothetical protein | - |
GJV83_RS23660 | 13413..14642 | + | 1230 | WP_001329504.1 | relaxase/mobilization nuclease domain-containing protein | - |
GJV83_RS23665 | 14719..15012 | + | 294 | WP_060598542.1 | LuxR family transcriptional regulator | - |
GJV83_RS23670 | 15009..15224 | + | 216 | WP_000760375.1 | EexN family lipoprotein | - |
GJV83_RS23675 | 15580..16200 | + | 621 | WP_000157549.1 | lytic transglycosylase domain-containing protein | - |
GJV83_RS23680 | 16268..16540 | + | 273 | WP_001328551.1 | TrbC/VirB2 family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | mcr-1.1 | - | 1..34645 | 34645 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 83 a.a. Molecular weight: 9422.08 Da Isoelectric Point: 10.4800
>T144260 WP_000520549.1 NZ_CP046418:11953-12201 [Escherichia coli]
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
LL
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
LL
Download Length: 249 bp
>T144260 NZ_CP061801:c1143047-1142829 [Enterobacter mori]
ATGTCTGATAAACCATTAACCAAGATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATAGACACGCTGGAACGTGT
AATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCTGTATTTTATTCAGCGGCTGACCATCGTCTTGCTGAGC
TAACAATGAATAAACTGTATGACAAAATCCCCTCTTCTGTGTGGAAATTTGTCCGTTAA
ATGTCTGATAAACCATTAACCAAGATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATAGACACGCTGGAACGTGT
AATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCTGTATTTTATTCAGCGGCTGACCATCGTCTTGCTGAGC
TAACAATGAATAAACTGTATGACAAAATCCCCTCTTCTGTGTGGAAATTTGTCCGTTAA
Antitoxin
Download Length: 116 a.a. Molecular weight: 13113.84 Da Isoelectric Point: 4.6723
>AT144260 WP_000681613.1 NZ_CP046418:12198-12545 [Escherichia coli]
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA
Download Length: 348 bp
>AT144260 NZ_CP061801:c1143449-1143075 [Enterobacter mori]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCACGGCTGGGTGAACGATCCTACGTCTGCTATCAATTTACAGCTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTGATTGAGCAAATTGACGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAAAAATGGCGTAAATCTGGGAATCGTCT
ATTTCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCTGTTAGCCTTTCCTGTTAA
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCACGGCTGGGTGAACGATCCTACGTCTGCTATCAATTTACAGCTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTGATTGAGCAAATTGACGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAAAAATGGCGTAAATCTGGGAATCGTCT
ATTTCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCTGTTAGCCTTTCCTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CIX3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CLC1 |